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J. Funct. Biomater. 2013, 4(1), 14-26; doi:10.3390/jfb4010014

Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device

1
Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA
2
Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
3
Department of Cardiothoracic Surgery, University of Utah, Salt Lake City, UT 84112, USA
4
Department of Mechanical Engineering, University of Utah, Salt Lake City, UT 84112, USA
*
Author to whom correspondence should be addressed.
Received: 1 November 2012 / Revised: 17 December 2012 / Accepted: 11 January 2013 / Published: 18 January 2013
(This article belongs to the Special Issue Advances in Ophthalmic Biomaterials)
View Full-Text   |   Download PDF [2392 KB, 22 January 2013; original version 18 January 2013]   |  

Abstract

The capsule drug ring (CDR) is a reservoir and delivery agent, which is designed to be placed within the capsular bag during cataract surgery. Prototypes were manufactured by hot melt extrusion of Bionate II®, a polycarbonate urethane. The devices have been optimized using Avastin® as the drug of interest. In vitro biocompatibility was assessed with human lens epithelial cell (B-3), mouse macrophage (J774A.1) and mouse fibroblast (L-929) cell lines. Cell migration and proliferation were assessed after in vitro culture. Pro-inflammatory cytokines (i.e., MIP-1β, MIP-1α, MCP-1, IL-1β, TNF and TGF-β1) were quantified using cytometric bead array (CBA). Preliminary in vivo biocompatibility and pharmacokinetics testing has been performed in rabbits. View Full-Text
Keywords: CDR; capsular bag; drug delivery; biocompatibility CDR; capsular bag; drug delivery; biocompatibility
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Gooch, N.; Burr, R.M.; Holt, D.J.; Gale, B.; Ambati, B. Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device. J. Funct. Biomater. 2013, 4, 14-26.

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