Next Article in Journal
Targeting Metabolic Modulation and Mitochondrial Dysfunction in the Treatment of Heart Failure
Previous Article in Journal
Milk’s Role as an Epigenetic Regulator in Health and Disease
Previous Article in Special Issue
The Cardiovascular Effects of Cocoa Polyphenols—An Overview
Article Menu

Export Article

Open AccessReview
Diseases 2017, 5(2), 13; doi:10.3390/diseases5020013

The Role of the MAPK Signaling, Topoisomerase and Dietary Bioactives in Controlling Cancer Incidence

1
Interfaculty Institute of Microbiology and Infection Medicine, Eberhard Karls Universität Tübingen, 72076 Tübingen, Germany
2
Pharmaceutical and Drug Industries Research Division, National Research Centre, 33-El-Bohouth St. (former El Tahrir St.), Dokki, P.O. Box 12622, Giza, Egypt
3
Genetic Engineering and Biotechnology Research Division, National Research Centre, 33-El-Bohouth St. (former El Tahrir St.), Dokki, P.O. Box 12622, Giza, Egypt
4
Institute of Immunology, Ulm University, 89081 Ulm, Germany
5
National Center for Natural Products Research, School of Pharmacy, University of Mississippi, Oxford, MS 38677, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Received: 30 December 2016 / Revised: 16 April 2017 / Accepted: 19 April 2017 / Published: 26 April 2017
View Full-Text   |   Download PDF [2410 KB, uploaded 26 April 2017]   |  

Abstract

Reactive oxygen species (ROS) are common products of mitochondrial oxidative phosphorylation, xenobiotics metabolism and are generated in response to several environmental stress conditions. Some of them play important biochemical roles in cellular signal transduction and gene transcription. On the other hand, ROS are known to be involved in a wide range of human diseases, including cancer. The excessive production of such ROS together with disruption of homeostasis detoxifying mechanisms can mediate a series of cellular oxidative stresses. The oxidative stress of redundant free radicals production can lead to oxidative denaturation of cellular macromolecules including proteins, lipids and DNA. Moreover, oxidative damage is one of the major causes of DNA mutations, replication errors and genomic abnormalities which result in either inhibition or induction of transcription, and end with the disturbance of signal transduction pathways. Among affected signaling pathways are redox-sensitive kinases. The stimulation of these kinases induces several transcription factors through the phosphorylation of their module proteins. The activation of such pathways induces proliferation and cellular transformation. A diet rich in antioxidant compounds has potential health benefits, and there is a growing interest in the role of natural antioxidants in nutrition for prevention and cure of cancer diseases. A controversy has risen regarding the relation between antioxidants and the significant decrease in the risk of cancer incidence. In this review, we will focus on redox-sensitive kinases signaling pathways, highlighting the effects of dietary antioxidant on the prevention, incidence, prognosis or even treatment of human cancers. In addition, we will place emphasis on the chemical classes of pterocarpans as natural anti-oxidants/cancers as well as their underlying mechanisms of action, including their effects on MAPKs and topoisomerase activities. View Full-Text
Keywords: dietary antioxidants; MAPK kinases; MAPK phosphatases; pterocarpans; ROS; topoisomerase dietary antioxidants; MAPK kinases; MAPK phosphatases; pterocarpans; ROS; topoisomerase
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Selim, K.A.; Abdelrasoul, H.; Aboelmagd, M.; Tawila, A.M. The Role of the MAPK Signaling, Topoisomerase and Dietary Bioactives in Controlling Cancer Incidence. Diseases 2017, 5, 13.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Diseases EISSN 2079-9721 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top