Table of Contents
Metabolites, Volume 7, Issue 4 (December 2017)
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Cover Story (view full-size image) Sepsis represents a severe immune dysregulation, secondary to systemic infection. The burden of [...] Read more. Sepsis represents a severe immune dysregulation, secondary to systemic infection. The burden of sepsis is pronounced—the incidence is increasing and sepsis represents a leading cause of mortality internationally, particularly in the intensive care setting. The need for comprehensive and novel strategies for both assessing and treating sepsis are underlined by the lack of both sepsis-specific biomarkers and treatments. The endocannabinoid system (ECS) is an emerging area of research interest and is intrinsically linked to various key aspects of the immune function. As such, assessing potential biomarkers of the ECS may be a promising novel tool in the diagnosis and stratification of sepsis patients, as well as in guiding immunomodulatory therapies that target sepsis-induced immune dysregulation. View the paper