- freely available
Sumoylation and the DNA Damage Response
AbstractThe cellular response to DNA damage involves multiple pathways that work together to promote survival in the face of increased genotoxic lesions. Proteins in these pathways are often posttranslationally modified, either by small groups such as phosphate, or by protein modifiers such as ubiquitin or SUMO. The recent discovery of many more SUMO substrates that are modified at higher levels in damage conditions adds weight to the accumulated evidence suggesting that sumoylation plays an important functional role in the DNA damage response. Here we discuss the significance of DNA damage-induced sumoylation, the effects of sumoylation on repair proteins, sumoylation dynamics, and crosstalk with other posttranslational modifications in the DNA damage response.
Share & Cite This Article
Cremona, C.A.; Sarangi, P.; Zhao, X. Sumoylation and the DNA Damage Response. Biomolecules 2012, 2, 376-388.View more citation formats
Cremona CA, Sarangi P, Zhao X. Sumoylation and the DNA Damage Response. Biomolecules. 2012; 2(3):376-388.Chicago/Turabian Style
Cremona, Catherine A.; Sarangi, Prabha; Zhao, Xiaolan. 2012. "Sumoylation and the DNA Damage Response." Biomolecules 2, no. 3: 376-388.
Notes: Multiple requests from the same IP address are counted as one view.