Next Article in Journal
Why YRNAs? About Versatile RNAs and Their Functions
Previous Article in Journal
Application of Metabolic 13C Labeling in Conjunction with High-Field Nuclear Magnetic Resonance Spectroscopy for Comparative Conformational Analysis of High Mannose-Type Oligosaccharides
Biomolecules 2013, 3(1), 124-142; doi:10.3390/biom3010124

Regulation of Mammalian Gene Dosage by Long Noncoding RNAs

RNA biology program, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 21 December 2012 / Revised: 23 January 2013 / Accepted: 25 January 2013 / Published: 4 February 2013
View Full-Text   |   Download PDF [509 KB, uploaded 4 February 2013]   |   Browse Figures


Recent transcriptome studies suggest that long noncoding RNAs (lncRNAs) are key components of the mammalian genome, and their study has become a new frontier in biomedical research. In fact, lncRNAs in the mammalian genome were identified and studied at particular epigenetic loci, including imprinted loci and X-chromosome inactivation center, at least two decades ago—long before development of high throughput sequencing technology. Since then, researchers have found that lncRNAs play essential roles in various biological processes, mostly during development. Since much of our understanding of lncRNAs originates from our knowledge of these well-established lncRNAs, in this review we will focus on lncRNAs from the X-chromosome inactivation center and the Dlk1-Dio3 imprinted cluster as examples of lncRNA mechanisms functioning in the epigenetic regulation of mammalian genes.
Keywords: epigenetics; lncRNA; genomic imprinting; X-inactivation; Gtl2; Xist epigenetics; lncRNA; genomic imprinting; X-inactivation; Gtl2; Xist
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Hung, K.-H.; Wang, Y.; Zhao, J.C. Regulation of Mammalian Gene Dosage by Long Noncoding RNAs. Biomolecules 2013, 3, 124-142.

View more citation formats

Related Articles

Article Metrics


[Return to top]
Biomolecules EISSN 2218-273X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert