### AChE inhibition Model

Parameter | Value
--- | ---
Endpoint | Fathead minnow LC50 (96 hr)
r2 | 0,853
q2 | 0,780
#chemicals | 36
Model | AChE inhibition Model

Model coefficients
Coefficient | Definition | Value | Uncertainty*
--- | --- | --- | ---
Intercept | Model intercept | 3,2120 | 0,4692
xch5 | Simple 5th order chain chi index | 16,4876 | 4,9506
knotpv | Difference between chi valence cluster-3 and chi valence path/cluster-4. | 0,5705 | 0,2056
SdsN_acnt | Count of ( = N – ) (SdsN_acnt) | 1,0148 | 0,3269
TIE | E-state topological parameter | 0,0127 | 0,0076
GATS7p | Geary autocorrelation - lag 7 / weighted by atomic polarizabilities | -0,4225 | 0,2075
XLOGP | Wang octanol water partition coefficient | 0,6340 | 0,0974
P(=O) | P(=O) fragment count | 0,6182 | 0,3305

* value for 90% confidence interval

Model equation:
Fathead minnow LC50 (96 hr) = 16,4876×(xch5) + 0,5705×(knotpv) + 1,0148×(SdsN_acnt) + 0,0127×(TIE) - 0,4225×(GATS7p) + 0,6340×(XLOGP) + 0,6182×(P(=O)) + 3,2120

AChE inhibition LC50 fit results by chemical AChE inhibition LC50 training set descriptors