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Foods 2012, 1(1), 40-51; doi:10.3390/foods1010040

Application of Gut Cell Models for Toxicological and Bioactivity Studies of Functional and Novel Foods

Department of Biochemistry and Nutrition, University of Maribor, Faculty of Medicine, Slomskov trg 15, Maribor 2000, Slovenia
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Received: 30 October 2012 / Revised: 30 November 2012 / Accepted: 4 December 2012 / Published: 13 December 2012
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Abstract

The concept of functional and novel foods undoubtedly bears great potential as an asset to human health. However, this very same quest for ever new bioactive ingredients calls for reliable and distinct risk assessment as they may be potentially hazardous to human health. Most of today's methodologies still rely on decades old routines of animal trials and use of tumor-derived cell lines. Since such methodologies are not in line with the actual processes in the human body and with the 3R (replacement, reduction, refinement) concept, the results are often unreliable and misleading. Therefore, in this paper we propose the utilization of available untransformed small intestinal cell lines derived from human and pig tissue of non-tumor origin and describe several available cell models of the gut that offer a functional, close resemblance with the in vivo environment. View Full-Text
Keywords: gut; cell models; risk assessment; toxicology; functional food gut; cell models; risk assessment; toxicology; functional food
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Trapecar, M.; Cencic, A. Application of Gut Cell Models for Toxicological and Bioactivity Studies of Functional and Novel Foods. Foods 2012, 1, 40-51.

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