The Lipid Lowering and Cardioprotective Effects of Vernonia calvoana Ethanol Extract in Acetaminophen-Treated Rats
Abstract
:1. Introduction
2. Materials and Methods
2.1. Procurement of Leaves, Rat Chow and Acetaminophen
2.2. Preparation of Extract
2.3. Experimental Animals
2.4. Extract and Drug Administration
2.5. Preparation of Serum for Biochemical Assays
2.6. Assay of Selected Lipid Parameters
2.7. Statistical Analysis
3. Results
3.1. Effects of V. calvoana on Total Cholesterol (TC) Concentration
3.2. Effect of V. calvoana on Triacylglycerol Concentration
3.3. Effect of Treatment on High-Density Lipoprotein Cholesterol
3.4. Effect of Treatment on the Low-Density Lipoprotein Cholesterol
3.5. Effect of Treatment on Atherogenic Index
4. Discussion
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Group | Number of Animals | Treatment |
---|---|---|
Group 1 | 7 | Normal saline |
Group 2 | 7 | 2 g/kg paracetamol only |
Group 3 | 7 | 2 g/kg paracetamol + 200 mg/kg b.w. VC |
Group 4 | 7 | 2 g/kg paracetamol + 400 mg/kg b.w. VC |
Group 5 | 7 | 2 g/kg paracetamol + 100 mg/kg b.w. Vit. E |
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Egbung, G.E.; Atangwho, I.J.; Odey, O.D.; Ndiodimma, V.N. The Lipid Lowering and Cardioprotective Effects of Vernonia calvoana Ethanol Extract in Acetaminophen-Treated Rats. Medicines 2017, 4, 90. https://doi.org/10.3390/medicines4040090
Egbung GE, Atangwho IJ, Odey OD, Ndiodimma VN. The Lipid Lowering and Cardioprotective Effects of Vernonia calvoana Ethanol Extract in Acetaminophen-Treated Rats. Medicines. 2017; 4(4):90. https://doi.org/10.3390/medicines4040090
Chicago/Turabian StyleEgbung, Godwin Eneji, Item Justin Atangwho, Ochuole Diana Odey, and Victor Ndubuisi Ndiodimma. 2017. "The Lipid Lowering and Cardioprotective Effects of Vernonia calvoana Ethanol Extract in Acetaminophen-Treated Rats" Medicines 4, no. 4: 90. https://doi.org/10.3390/medicines4040090