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Proceedings 2017, 1(10), 1066; doi:10.3390/proceedings1101066

Ameliorative Effects of Carvacrol on Cyclophosphamide-Induced Testis Damage and Oxidative Stress

1
Department of Mathematics and Science Education, Education Faculty, Siirt University, Siirt 56100, Turkey
2
Biology Department, Art and Science Faculty, Eskişehir Osmangazi University, Eskişehir 26040, Turkey
3
Vocational School of Health Services, Eskişehir Osmangazi University, Eskişehir 26040, Turkey
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
*
Author to whom correspondence should be addressed.
Published: 15 November 2017
Download PDF [137 KB, uploaded 15 November 2017]

Abstract

Cyclophosphamide (CP) is an effective drug widely used for treating clinical cancer and non-malignant diseases. However, using CP causes cytotoxicity in one or more tissues. The present study aims to investigate possible protective effects of Carvacrol (Cr), which is an essential component of thyme and also known for its antioxidant properties, upon testis toxicity. For this study, 35 male rats were categorized into 5 groups, each of them including 7 members. Blood samples and testis tissues were obtained from each animal for the evaluation of biochemical markers and histopathological examination. Assessment of serum and testis sampled revealed that Cr has a significant role in protecting against CP-caused testis damage. Our data also show that Cr is a very effective antioxidant with cell-protecting properties. For this reason, we conclude that Cr could help reduce the side-effects of anticancer drugs as far as chemotherapy protocols are concerned.
Keywords: Cyclophosphamide; Carvacrol; Testes Damage; Antioxidant; Oxidative Stress Cyclophosphamide; Carvacrol; Testes Damage; Antioxidant; Oxidative Stress
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Cengiz, M.; Teksoy, O.; Sahinturk, V.; Tekin, Y.; Gunes, S.; Ayhanci, A. Ameliorative Effects of Carvacrol on Cyclophosphamide-Induced Testis Damage and Oxidative Stress. Proceedings 2017, 1, 1066.

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