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Proceedings 2017, 1(10), 1068; doi:10.3390/proceedings1101068

Cytotoxic Potentials of Some Asteraceae Plants from Turkey on HeLa Cell Line

1
Pharmacognosy Dept., Faculty of Pharmacy, Erciyes University, Kayseri 38039, Turkey
2
Pharmacognosy Dept., Faculty of Pharmacy, Hacettepe University, Ankara 06100, Turkey
3
Botany Dept., Faculty of Science and Letters, Uludağ University, Bursa 16059, Turkey
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
*
Author to whom correspondence should be addressed.
Published: 15 November 2017
Download PDF [157 KB, uploaded 15 November 2017]

Abstract

Screening of plants plays a considerable role in the discovery of new biologically active compounds. In the past few decades, numerous useful antineoplastic drugs were discovered in higher plants by following up ethnomedicinal uses or as a result of antitumor screening. Many plants in the Asteraceae family are used in folk medicine for a variety indications all over the world, but only limited data are available concerning the anticancer effects. Asteraceae is the richest family not an only number of the species but also rate of endemism in the flora of Turkey. In the current study, the methanol extracts of Asteraceae species from Turkey [Achillea setacea, Achillea sieheana, Achillea cucullata, Inula fragilis, Inula oculus-christi, Centaurea foliosa, Centaurea ertugriliana, Calendula suffruticosa, Erigeron acer] were tested against HeLa cell line in different concentrations (200 µg/mL, 100 µg/mL, 50 µg/mL, 25 µg/mL, 12.5 µg/mL, 6.25 µg/mL). Cell viability assessed with colorimetric MTT assay after 48 h treatment. According to the results; all tested extracts decreased cell viability in a dose dependent manner. The methanol extract of Centaurea ertugriliana is the most active extract and it has a significant cytotoxic activity with 32.35 µg/mL IC50 value on HeLa cell line.
Keywords: Asteraceae; cytotoxicity; HeLA Asteraceae; cytotoxicity; HeLA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Uzun, K.; İkiz, P.; Daşkın, R.; Gürbüz, P.; Yalçın, F.N. Cytotoxic Potentials of Some Asteraceae Plants from Turkey on HeLa Cell Line. Proceedings 2017, 1, 1068.

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