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Original Submission Date Received: .
In the last two decades the progress of knowledge on molecular genetics and the availability of high-throughput technologies has offered the opportunity to identify new diagnostic and prognostic markers and new therapeutic targets in human cancer. Among the several different high-throughput technologies made available, tissue microarray (TMA) technology has significantly accelerated in situ studies of tissue specimens, to explore associations between molecular changes and clinico pathological information and to ensure preservation of unique and precious research materials. In this issue we are inviting material about new developments and applications of tissue microarray based technology, mainly in field of translational cancer research including screening for diagnostic, prognostic as well as predictive biomarkers, discovery of molecular alterations in different stages of tumor progression, assessment of new drug targets and quality controls.
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