Dietary Fructose and Glucose: The Multifacetted Aspects of Their Metabolism and Implication for Human Health

© 2019 by the authors; CC BY license

early life; fructose; sugar-sweetened beverages; cardiometabolic health; offspring; sucrose; high fructose corn syrup; diabetes; cardiovascular disease; obesity; developmental programming; developmental origins of health and disease (DOHaD); fructose; hypertension; kidney; next-generation sequencing; reprogramming; transcriptome; high fructose diet; cardiovascular disease (CVD); growing rat; fructose-induced NAFLD; lipogenesis; natural products; mitochondrial dysfunction; inflammatory pathways; insulin resistance; glucose; fructose; sucrose; sugar ingestion; appetite; gut hormones; ghrelin; GLP-1; hepatic metabolism; breastfeeding; breast milk; maternal programming; added sugars; fructose; sugars; linear programming; nutrient recommendations; dietary habits; snacking; France; INCA2; substrate utilization; stable isotopes; metabolism; sugar; carbohydrates; glucose; fructose; type 1 diabetes; exercise; glycaemia; substrate oxidation; carbohydrate response element binding protein; ChREBP; glycolysis; fructolysis; Glut5/SLC2A5; ketohexokinase; fructose; intrahepatocellular lipid concentration; cardiovascular risk factors; fructose; hypertriglyceridemia; fructose; nonalcoholic fatty liver disease; liver; gut; muscle; fructose supplementation; glucose; fructose; sugar ingestion; gastric emptying; gastrointestinal adaptation; gastrointestinal hormones; simple sugars; high-fat diet; adipose tissue; inflammasome; metabolism; fructose-rich diet; mitochondrial biogenesis; mitochondrial DNA (mtDNA); oxidative damage; repair mechanisms; fructose; development; pregnancy; metabolism; type II diabetes; fructose; out-of-phase feeding; AMPK; corticosterone; melatonin; high dietary fructose; metabolites; metabolic syndrome; insulin resistance; oxidative stress; inflammation; tissue and organ dysfunction; carbohydrates; glycogen; liver; metabolism; muscle; resynthesis; sports nutrition; sucrose; fructose; chylomicron; very low-density lipoprotein; triglyceride-rich lipoproteins; cardiovascular disease; de novo lipogenesis; post-prandial; apoB48; gluconeogenesis; glucagon-like peptide; fructose; inborn errors of metabolism; toxicity; beta-cell function; diet; fructose; glucose; insulin sensitivity; prediabetes; sucrose; type 2 diabetes; glycemic index; isomaltulose; glucose metabolism; diabetes mellitus; weight-loss maintenance; clinical trials; fertility and pregnancy outcome; sweetened beverages; advanced glycation end products; fructose; glucose; lipogenesis; sphingolipids; NLRP3; Nrf2; mitochondrial dysfunction; oxidative stress; microbiota; renal oxidative stress; sucrose; fructose; obesity; LPS; inflammation; fructose; uric acid; cardiometabolic disorders; xanthine oxidase; pathophysiology; epidemiology; fructose; obesity; liver; aerobic exercise; strength exercise; combined exercise; glucose; fructose; lactate; lactate metabolism; substrate oxidation; carbohydrate; exercise; sweet taste receptor; GLP-1; GIP; glucose; sucralose; fructose; glucocorticoid; obesity; metabolic syndrome; adipogenesis; metabolic memory; type 2 diabetes mellitus; diabetic complications; obesity; fatty liver disease; hepatic steatosis; carbohydrate; glucose; fructose; aspartame; gut microbiota; fructose-rich diet; adipose tissue; probiotics; fructose; physical activity; metabolic syndrome; inflammation; insulin resistance; hyperlipidemia; sugar-sweetened beverages; diet quality; abdominal obesity; type 2 diabetes; cardiovascular diseases; sweet taste receptors; glucose sensing; nutrient sensing; leptin; hypothalamus; sugar; glucose transport; hexokinase; metabolism; muscle; energetics; evolution; foraging behavior