Special Issue "B Cells and Immunological Tolerance"
A special issue of Antibodies (ISSN 2073-4468).
Deadline for manuscript submissions: closed (31 August 2013)
Dr. Dat Q. Tran
Division of Pediatric Research Center, Department of Pediatrics, The University of Texas Medical School at Houston, Houston, TX 77030, USA
Interests: immunity; autoimmunity; tolerance; tregs; regulatory T cells; bregs; B cells; autoantibodies; immune regulation
In this special issue on B cells and immunological tolerance, we will offer an updated knowledge and new perspectives on the multitude of interactions between the B cells and their environment in order to build a fortress against invaders and peace among the citizens. Any perturbations in this harmony and fortitude within the B cells or their communications among different cells can weaken immunity and increase susceptibility to autoimmunity and allergy. As an integral part of the humoral immunity, the B cells play a vital component in the host defense against various microbes, viruses, fungi and toxins. Their antibodies are the missiles and satellites that provide this protection by directly targeting their enemies and communicating between innate and adaptive immunity to amplify their attack. A stringent control on the factories of the B cells is critical to prevent erroneous manufacturing of these antibodies, which could result in off-target injuries to the host.
In the last decade and more recently, we have gained tremendous insights into their machinery, alliances and regulation. They can produce a variety of cytokines to orchestrate the efficiency of other effector cells. They can be regulated and instructed by various cells including follicular helper T cells (Tfh), follicular regulatory T cells (Tfr) and regulatory T cells (Tregs). Their equilibrium between effective immunity and excessive inflammation in order to maintain immunological tolerance also depends on a unique B cell subset called regulatory B cells (Bregs). Through better understanding of these processes and intricate networks, we are able to develop preventative strategies and curative therapies to enhance immunity and eliminate allergic and autoimmune diseases. To put everything into perspective, this special issue will provide a concise review on the machinery and various interactions of B cells with their environment including platelets, Tregs, Tfh, Tfr, Bregs and probiotics that are necessary to maintain immune homeostasis and a balance between immunity and immunological tolerance.
Dr. Dat Q. Tran
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibodies is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 300 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
- B cells
- regulatory B cells (Bregs)
- regulatory T cells (Tregs)
- follicular helper T cells (Tfh)
- follicular regulatory T cells (Tfr)
- multiple sclerosis