Cytotoxic T Lymphocytes

Dear Colleagues,

As central effectors of adaptive immunity, cytotoxic T lymphocytes are essential for efficient immunosurveillance and clearance of pathogens and transformed cells. Aberrant cytotoxic T cell activity, both insufficient and excessive, underlies a number of prevalent immunodeficiencies and autoimmune diseases.

Novel immunotherapeutic strategies that aim at the activation of targeted cytotoxicity are currently at the forefront in the treatment of infectious diseases and cancer. In fact, recent developments in adoptive T cell therapies and antibody-based immune checkpoint inhibitors have seen some of the greatest breakthroughs in the treatment of refractory metastatic malignancies.

Understanding the processes driving cytotoxic T cell activity in both health and disease is therefore key for advancing therapies that either curb or potentiate T cell functions in a wide variety of pathologies.

This Special Issue of Antibodies focuses on the fundamental mechanisms that underpin cytotoxic T cell responses, as well the development of new therapeutic agents that modulate cytotoxic T cell function.

Dr. Maté Biro
Dr. Marcia Munoz
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibodies is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• cytotoxic T cells
• immunotherapy
• cancer
• adoptive T cell therapy
• immune checkpoint inhibitors