Special Issue "Natural Killer (NK) Cells"
A special issue of Antibodies (ISSN 2073-4468).
Deadline for manuscript submissions: closed (31 October 2013)
Dr. Taku Kambayashi
Division of Transfusion Medicine and Therapeutic Pathology, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
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Interests: mouse NK cell education; inhibitory receptors; activating receptors; signal transduction; cytotoxicity
Natural killer (NK) cells play an important role in defense against tumors and infections. When activated, NK cells can produce proinflammatory cytokines and directly eradicate tumor or pathogen-infected cells by mediating cytotoxicity. One important mechanism by which NK cells recognize target cells is through interaction of their Fcγ receptor with IgG-coated targeted cells or IgG immune complexes. Ligation of the Fcγ receptor involves the phosphorylation of immunotyrosine-based activation motif (ITAM)s in the intracellular portion of the Fcγ chain leading to downstream signal transduction events important for NK cell responses. Activation through ITAM-bearing immunoreceptors is critical for NK cell development and function in pathological and non-pathological states.
This special issue of Antibodies is focused on NK cell activation through Fcγ receptors or by other immunoreceptors utilizing ITAM-bearing adaptors and I kindly invite you to submit your novel results to this special issue. Welcome are manuscripts describing in vitro or in vivo function of NK cells activated through these receptors, signal transduction through these receptors, and acquisition or effects of these receptors in NK cell development or homeostasis.
Dr. Taku Kambayashi
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibodies is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 350 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- NK cells
- Fcγ receptor
- antibody-dependent cellular cytotoxicity (ADCC)
- signal transduction
- NK cell development
- NK cell effector function
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of Paper: Article
Title: Antibodies and Natural Killer Cells
Authors: RJ Aicheler and GWG Wilkinson
Affiliation: Section of Medical Microbiology, Tenovus Building, School of Medicine, Cardiff University, Cardiff, United Kingdom
Abstract: NK cells are critically important for the control of Human Cytomegalovirus (HCMV) infection in the host. To date, 8 NK immunomodulatory functions encoded by HCMV have been characterised, 7 of these modulate the ability of the NK cell to degranulate in response to HCMV infected cells by modulating NK cell ligand expression and one targets TRAILR2, a member of the death receptor pathway. Although 90% of NK cells express the Fc receptor CD16 and so would be expected to initiate Antibody Dependent Cellular Cytotoxicity (ADCC), little work has been carried out to characterise viral clearance through ADCC. Classically, CD16 is found on the surface of the NK cell in a complex with the two FcRγ chains and two CD3ζ chains. Recent studies have identified a novel population of NK cells that are FcRγ negative and have reduced levels of CD16 on their surface. HCMV has a profound effect on the NK cell repertoire such that 10 fold expansions of NKG2C+ cells can be seen in HCMV seropositive individuals as compared to seronegative donors. Two recent papers have published data indicating that these NKG2C+ are FcRγ negative CD16lo and have striking ADCC functions. These data not only give a function to a hitherto identified population of expanded NK cells in HCMV seropositive donors but also are the first demonstration of clearance of HCMV infected target cells by ADCC.