Dear Colleagues,

Magnetic hyperthermia treatment (MHT) is based on the well-established evidence that cancer cells are more sensitive than cells deriving from a healthy tissue to temperatures higher than 41 °C. Various approaches like whole body hyperthermia, radiofrequency hyperthermia, and inductive hyperthermia were employed in the past to raise the temperature of tissues. The critical issue of these methods is related to the achievement of the selective heating only to the pathological region, since an unspecific extended hyperthermia treatment could damage healthy tissues. In this respect, superparamagnetic iron oxide nanoparticles (SPIONs) due to their small size, offer a real alternative to induce a spatially-specific increase of the temperature during the treatment. MHT consists in the localized heating of the immediate surroundings of a magnetic nanoparticle through the application of an alternated magnetic field. Because of the increase in temperature, the treated cells can be depleted, thus, inducing a cellular necrosis. As proof of the applicability of SPIONs  in clinical, it is noteworthy to report that in the last few years several formulations based on these nanoparticles have been used as a contrast agent for MRI or MPI, or as a carrier for drug delivery. Moreover, recently magnetic nanoparticles have been also direct injected in solid tumor, in clinical settings, for the treatment of glioblastoma by thermotherapy.

This Special Issue of the journal Applied Sciences, “Magnetic Nanoparticles for Hyperthermia Applications”, aims to cover recent advances in the design of magnetic nanoparticles for applications in magnetic hyperthermia, considering both the preparation of novel colloidal formulations and/or technological advances for theranostic applications of these nanoparticles.

Dr. Riccardo Di Corato
Guest Editor

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• Magnetic Nanoparticles
• Magnetic Hyperthermia
• Cancer
• Nanomedicine
• Theranostics
• Drug Delivery
• Combined therapy
• Medical imaging