Dear colleagues,

Every year millions of people suffer from the effects of disease or degeneration in tissues and organs. Due to the limited number of organ donors, there has been an increasing need for tissue-engineered constructs or strategies to induce regenerative repair after injury (e.g., heart, blood vessels, liver, lung, bone, cartilage, kidney). The ultimate goal of regenerative engineering is to repair or replace damaged tissues by converging the principles from developmental biology, stem cell biology, materials science, engineering, and medicine. In this context, biomaterial-based approaches are promising strategies. A key enabling technology for these approaches is the development of functional biomaterials containing instructive signals to modulate cell behavior.

Hydrogel-based biomaterials have been widely used in tissue engineering and regenerative medicine research, particularly to facilitate cell-cell and cell- biomaterial interactions in a controlled manner. In this Special Issue, we will include example papers for hydrogel-based biomaterials. We will also cover a wider range of biomaterial variants (e.g., porous scaffolds, nano- and micro-particles, synthetic or naturally derived polymers, proteins, carbohydrates, lipids) that highlight research results from basic science to clinical applications. This issue will also highlight the applications of these biomaterial technologies to create instructive microenvironments to control cell fate such as self-renewal, quiescence and differentiation. In addition, microfabrication techniques for regenerative engineering, such as implementation of microfluidic tools and bioprinting approaches will also be covered in this Special Issue.

Dr. Gulden Camci-Unal

Guest Editor

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