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Mesoporous Materials in Drug Delivery and Regenerative Engineering 2016

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A special issue of Bioengineering (ISSN 2306-5354).

Deadline for manuscript submissions: closed (20 December 2016) | Viewed by 33721

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Special Issue Editors

Prof. Dr. Chiara Vitale-Brovarone

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Guest Editor

Department of Applied Science and Technology, Politecnico di Torino, 10100 Turin, Italy
Interests: bioceramics; mesoporous glasses and nanomaterials; collagen; bone regeneration and osteoporosis; drug-delivery; 3D scaffolds; biofabrication; electropinning; injectable cements
Special Issues, Collections and Topics in MDPI journals

Prof. Dr. Sonia Fiorilli

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Co-Guest Editor

Department of Applied Science and Technology, Politecnico di Torino, 10129 Torino, Italy
Interests: mesoporous bioactive glasses; hybrid organic-inorganic nanomaterials; drug release
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Prof. Dr. Aldo R. Boccaccini

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Co-Guest Editor

Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, 91058 Erlangen, Germany
Interests: bioactive glasses; bioceramics; composite coatings; biofabrication; scaffolds; tissue engineering
Special Issues, Collections and Topics in MDPI journals

Prof. Dr. María Vallet-Regí

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Co-Guest Editor

CIBER-BBN and Department of Chemistry in Pharmaceutical Sciences, Universidad Complutense de Madrid (UCM), Av. Séneca, 2, 28040 Madrid, Spain
Interests: bioceramic-based bone grafting materials and scaffolds for regenerative biomedicine; production and study of bioceramic systems for controlled release of biotechnological and antitumoral species; nanoparticles and biocompatible matrices for biotechnological applications; silica-based ordered mesoporous materials as release systems of biologically active species; cell encapsulation in silica porous materials; mesoporous materials for gene therapy and transfection; organic–inorganic hybrid materials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The use of organized mesoporous materials in biomedical applications continues to gain interest due to their well-defined nanoporous structure of length scales (20–50 nm) that confer upon them the ability to store and release different molecules based on size, shape and surface charge. Mesoporous materials are also finding applications in regenerative engineering e.g., osseointegration.

The concept of using mesoporous materials in the field of drug delivery offers several advantages, including the ability

to incorporate large amounts of highly dispersed drug due to large specific surface area/pore volume
to host drug molecules spanning a wide range of sizes due to the tailorable pore size of the support
to guarantee an excellent stability of the payload against degradation due to a fine-tuned host–guest interaction
to control drug release kinetics by tailoring the features of the porous structure (e.g. pore inter-connectivity, ink bottle geometry, etc.)

In addition, mesoporous inorganic materials are amenable to surface functionalization which can enable tuning of the hydrophilic/hydrophobic character, allow encapsulation of a variety of drugs, and allow combination with other vehicles (e.g. polymers) to form bioactive composites. Moreover, surface modification can impart stimuli-responsive and/or targeting properties.

Mesoporous bioactive glasses (MBGs), which combine the textural parameters of ordered mesoporous matrices with the properties of conventional bioactive sol-gel glasses, have received increasing attention as bone-tissue regeneration systems. The ambition is to impart other biological functions, including anti-bacterial activity, as well as stimulation of osteogenesis and angiogenesis, by incorporating therapeutic factors.

Prof. Dr. Chiara Vitale-Brovarone
Guest Editor

Prof. Sonia Fiorilli
Prof. Aldo R. Boccaccini
Prof. María Vallet-Regí
Co-Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

Mesoporous materials
Drug loading and delivery
Ion release
Stimuli responsive
Tissue engineering
Regenerative engineering

Published Papers (3 papers)

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Research

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5394 KiB

Open AccessArticle

Biosilica from Living Diatoms: Investigations on Biocompatibility of Bare and Chemically Modified Thalassiosira weissflogii Silica Shells

by Stefania Roberta Cicco, Danilo Vona, Roberto Gristina, Eloisa Sardella, Roberta Ragni, Marco Lo Presti and Gianluca Maria Farinola

Bioengineering 2016, 3(4), 35; https://doi.org/10.3390/bioengineering3040035 - 16 Dec 2016

Cited by 51 | Viewed by 9038

Abstract

In the past decade, mesoporous silica nanoparticles (MSNs) with a large surface area and pore volume have attracted considerable attention for their application in drug delivery and biomedicine. Here we propose biosilica from diatoms as an alternative source of mesoporous materials in the field of multifunctional supports for cell growth: the biosilica surfaces were chemically modified by traditional silanization methods resulting in diatom silica microparticles functionalized with 3-mercaptopropyl-trimethoxysilane (MPTMS) and 3-aminopropyl-triethoxysilane (APTES). Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy analyses revealed that the –SH or –NH₂ were successfully grafted onto the biosilica surface. The relationship among the type of functional groups and the cell viability was established as well as the interaction of the cells with the nanoporosity of frustules. These results show that diatom microparticles are promising natural biomaterials suitable for cell growth, and that the surfaces, owing to the mercapto groups, exhibit good biocompatibility. Full article

(This article belongs to the Special Issue Mesoporous Materials in Drug Delivery and Regenerative Engineering 2016)

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Review

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2769 KiB

Open AccessReview

Composite Biomaterials Based on Sol-Gel Mesoporous Silicate Glasses: A Review

by Francesco Baino, Sonia Fiorilli and Chiara Vitale-Brovarone

Bioengineering 2017, 4(1), 15; https://doi.org/10.3390/bioengineering4010015 - 23 Feb 2017

Cited by 47 | Viewed by 10759

Abstract

Bioactive glasses are able to bond to bone and stimulate the growth of new tissue while dissolving over time, which makes them ideal materials for regenerative medicine. The advent of mesoporous glasses, which are typically synthesized via sol-gel routes, allowed researchers to develop a broad and versatile class of novel biomaterials that combine superior bone regenerative potential (compared to traditional melt-derived glasses) with the ability of incorporating drugs and various biomolecules for targeted therapy in situ. Mesoporous glass particles can be directly embedded as a bioactive phase within a non-porous (e.g., microspheres), porous (3D scaffolds) or injectable matrix, or be processed to manufacture a surface coating on inorganic or organic (macro)porous substrates, thereby obtaining hierarchical structures with multiscale porosity. This review provides a picture of composite systems and coatings based on mesoporous glasses and highlights the challenges for the future, including the great potential of inorganic–organic hybrid sol-gel biomaterials. Full article

(This article belongs to the Special Issue Mesoporous Materials in Drug Delivery and Regenerative Engineering 2016)

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5593 KiB

Open AccessReview

pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

by Miguel Gisbert-Garzarán, Miguel Manzano and María Vallet-Regí

Bioengineering 2017, 4(1), 3; https://doi.org/10.3390/bioengineering4010003 - 18 Jan 2017

Cited by 60 | Viewed by 13345

Abstract

The application of nanotechnology to medicine constitutes a major field of research nowadays. In particular, the use of mesoporous silica and carbon nanoparticles has attracted the attention of numerous researchers due to their unique properties, especially when applied to cancer treatment. Many strategies based on stimuli-responsive nanocarriers have been developed to control the drug release and avoid premature release. Here, we focus on the use of the subtle changes of pH between healthy and diseased areas along the body to trigger the release of the cargo. In this review, different approximations of pH-responsive systems are considered: those based on the use of the host-guest interactions between the nanocarriers and the drugs, those based on the hydrolysis of acid-labile bonds and those based on supramolecular structures acting as pore capping agents. Full article

(This article belongs to the Special Issue Mesoporous Materials in Drug Delivery and Regenerative Engineering 2016)

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