Ion Channels and Disease: Genetic and Transcriptional Channelopathies
A special issue of Biology (ISSN 2079-7737).
Deadline for manuscript submissions: closed (31 March 2017) | Viewed by 12494
Special Issue Editors
Interests: ion channels; channelopathies; brain tumor
Interests: ion channels; electrophysiology; patch clamp; molecular dynamics; glioblastoma
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Ion channels are membrane proteins that control several vital physiological functions in all cells. Defects in their function often result in disease states, now also designated as channelopathies. There are two main types of channelopathy: genetic and transcriptional. The former occurs when ion channels dysfunction results from a mutated protein, due to mutations in the coding region of its gene. Certain ataxias, arrithmias, and migraine, are some examples. More recently disorders caused by the abnormal expression of non-mutated channel genes have been reported. In this case, the disorders may either originate from a genetic mutation in the promoter region of the channel gene, in a gene coding for a non-channel protein, or may even have a non-genetic origin. These disorders have come to be identified as transcriptional channelopathies, and are most typical of cancer where ion channels are often found abnormally expressed. This Special Issue welcomes review articles on genetic and transcriptional channelopathies with the aim of updating the state-of-the-art in the area and provide a useful reference on these channelopathies.
Prof. Dr. Fabio Franciolini
Dr. Luigi Catacuzzeno
Guest Editors
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Keywords
- Ion channels
- genetic channelopathies
- transcriptional channelopathies
- disease
- gene mutations
- protein expression
