Special Issue "Next-Generation Immunosensors"
A special issue of Biosensors (ISSN 2079-6374).
Deadline for manuscript submissions: closed (31 July 2016)
Immunosensors are analytical devices based on the formation of antigen–antibody complexes, which are detected and converted to a signal, generally of an optical, electrochemical, or piezoelectric nature. Different trasducing mechanisms are employed in immunosensors, based on signal generation or on property changes, due to the formation of the antigen/antibody complex.
Immunosensors are considered a special type of biosensor, aiming at the detection of the presence of specific antibodies or antigens, and is particularly important in the case of diagnosis of deseases, and, further, is more significant when performed in remote areas, when lacking trained analysis or required facilities in underdeveloped countries, where carrying out immunoessays, such as ELISA (Enzyme linked Immunosorbent Assay), is not possible.
Different disciplines converge in an immunosensor: biology, chemistry, electronics, and the improvements can play on one or more of these three areas. Thus, the idea of a Special Issue on these kinds of devices is related to the willingness to contribute to the dissemination of new opportunities, able to monitor and, consequently, to fight epidemics and their spread.
Another aspect of possible innovations is represented by the possibility to extend the media to which these tools are applied. Commonly, they are body fluids, especially serum, where antibodies or antigens are determined; however, increasing interest concerns the detection of different analytes in diverse media, such as groundwater and vegetal samples.
Finally, a weakness of immunosensors is represented by their single use, because of the high stability of the antigen–antibody complex. Thus, regeneration of these devices appears to be a significant and relevant innovation.
Prof. Dr. Luigi Campanella
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