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Biosensors
Special Issues
Nanostructured Thin Films for Optical Biosensing
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Nanostructured Thin Films for Optical Biosensing

A special issue of Biosensors (ISSN 2079-6374).

Deadline for manuscript submissions: closed (29 February 2016) | Viewed by 8719

Special Issue Editor

Prof. Dr. Ibrahim Abdulhalim

E-Mail Website
Guest Editor
Department of Electro-Optics and Photonics Engineering and the Ilse-Katz Institute for Nanoscale Science and Technology, Ben Gurion University, Beer Sheva 84105, Israel
Interests: plasmonic biosensors; nanophotonic devices; liquid crystal optics and devices; spectropolarimetric imaging; interference microscopy; biomedical optics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue will be devoted to optical biosensors based on nanostructures in thin film form, including but not limited to: nanoparticles dispersed on substrates, periodic or random arrays on substrates, sculptured thin films, nanoislands, bioinspired nanostructures, and porous materials. Detection modes can be spectroscopic, angular, spectral, polarimetric, extinction, phase, imaging, photoacoustic, surface enhanced- fluorescnce (SEF), -Raman (SERS), -infrared absoption(SEIRA), etc. All types of application domains are acceptable.

Prof. Dr. Ibrahim Abdulhalim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plasmonics
  • nanostructured thin films
  • optical biosensors
  • surface enhanced spectroscopy (SERS, SEF, SEIRA)
  • label-free transduction
  • nanoparticles, CNTS, quantum dots
  • multiarray of micro/nanotransducers
  • porous materials

Published Papers (1 paper)

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Research

4551 KiB  
Article
Integrating Nanostructured Artificial Receptors with Whispering Gallery Mode Optical Microresonators via Inorganic Molecular Imprinting Techniques
by G. Denise Hammond, Adam L. Vojta, Sheila A. Grant and Heather K. Hunt
Biosensors 2016, 6(2), 26; https://doi.org/10.3390/bios6020026 - 15 Jun 2016
Cited by 6 | Viewed by 8087
Abstract
The creation of label-free biosensors capable of accurately detecting trace contaminants, particularly small organic molecules, is of significant interest for applications in environmental monitoring. This is achieved by pairing a high-sensitivity signal transducer with a biorecognition element that imparts selectivity towards the compound [...] Read more.
The creation of label-free biosensors capable of accurately detecting trace contaminants, particularly small organic molecules, is of significant interest for applications in environmental monitoring. This is achieved by pairing a high-sensitivity signal transducer with a biorecognition element that imparts selectivity towards the compound of interest. However, many environmental pollutants do not have corresponding biorecognition elements. Fortunately, biomimetic chemistries, such as molecular imprinting, allow for the design of artificial receptors with very high selectivity for the target. Here, we perform a proof-of-concept study to show how artificial receptors may be created from inorganic silanes using the molecular imprinting technique and paired with high-sensitivity transducers without loss of device performance. Silica microsphere Whispering Gallery Mode optical microresonators are coated with a silica thin film templated by a small fluorescent dye, fluorescein isothiocyanate, which serves as our model target. Oxygen plasma degradation and solvent extraction of the template are compared. Extracted optical devices are interacted with the template molecule to confirm successful sorption of the template. Surface characterization is accomplished via fluorescence and optical microscopy, ellipsometry, optical profilometry, and contact angle measurements. The quality factors of the devices are measured to evaluate the impact of the coating on device sensitivity. The resulting devices show uniform surface coating with no microstructural damage with Q factors above 106. This is the first report demonstrating the integration of these devices with molecular imprinting techniques, and could lead to new routes to biosensor creation for environmental monitoring. Full article
(This article belongs to the Special Issue Nanostructured Thin Films for Optical Biosensing)
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