Special Issue "Prognostic and Predictive Factors in Colorectal Cancer"
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (28 February 2011)
Dr. Alessandro Lugli
Deputy Chief Pathologist, Head, Division of Clinical Pathology, Institute of Pathology, University of Bern, Murtenstrasse 31, 3010 Bern, Switzerland
Fax: +41 31 632 49 95
Interests: gastrointestinal and liver tumors; tumor diagnosis and staging; prognostic and predictive biomarkers
Colorectal cancer (CRC) is one of the most common malignant diseases worldwide. Based on the chromosomal instability (CIN) and serrated pathways, CRC can be subdivided into mismatch-repair proficient (85%) and deficient (15%) tumors. In 2007, Jeremy Jass proposed a new molecular classification of CRC including KRAS, BRAF, mismatch-repair, CpG Island Methylator Phenotype (CIMP) and O-6-methylguanine-DNA methyltransferase (MGMT) status. According to the UICC/AJCC tumor extent, lymph node and distant metastasis, lymphatic and vascular invasion are considered the essential prognostic factors. Although several recent studies have proposed different histomorphological, immunohistochemical and molecular biomarkers to improve stratification of CRC patients into prognostic subgroups, there are no officially established additional prognostic and predictive factors included in the pre- and postoperative management of non-metastatic CRC. Due to the implementation of anti-EGFR therapy for metastatic CRC patients in the last years, predictive factors such as the KRAS mutational status are now included in the therapeutic assessment. This special issue of Cancers will include original contributions or review articles that focus on the prognostic and predictive value of molecular, immunohistochemical and histomorphological biomarkers to help improve the clinical management of CRC patients.
Dr. Alessandro Lugli
- TNM classification
- prognostic factors
- predictive factors
- mismatch repair status
- molecular biomarkers
- histomorphological factors