Intensity Modulated Radiation Therapy

A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: closed (15 August 2017) | Viewed by 13116

Special Issue Editor

Department of Radiation Physics - Pt Care, The University of Texas MD Anderson Cancer Center, Proton Therapy Center, 1840 Old Spanish, Houston, TX 77054, USA
Interests: proton therapy; optimization algorithm for radiation therapy; data mining and engineering in radiation therapy; high performance computing in medicine
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Special Issue Information

Dear Colleagues,

Intensity-modulated radiation therapy (IMRT), an advanced mode of high-precision radiotherapy, represents the major technological advance in radiation therapy in the last several decades. IMRT allows higher radiation doses to be focused to regions within the tumor while minimizing the doses to surrounding normal critical structures. This advance in delivery technology allows radiation to be delivered to patients in the form of step-and-shoot intensity-modulated x-ray therapy (IMXT), sliding window IMXT, volumetric modulated arc therapy (VMAT), and intensity-modulated proton therapy (IMPT). Because higher and more effective radiation doses can safely be delivered to tumors with fewer side effects compared with conventional radiotherapy techniques, IMRT is now becoming the standard of care for radiation therapy of most disease sites. IMRT is an ideal topic for researchers to exchange ideas and share state-of-the-art developments in different disciplines.

Dr. Xiaodong Zhang
Guest Editor

Keywords

  • IMRT
  • IMPT
  • VMAT
  • proton
  • optimization
  • inverse planning
  • radiomics
  • machine learning
  • big data
  • imaging guidance
  • dose calculation
  • PET
  • MRI
  • automatic planning
  • knowledge-based planning
  • data mining
  • outcome
  • statistical modeling
  • clinical workflow
  • quality assurance

Published Papers (2 papers)

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Review

26 pages, 298 KiB  
Review
Volumetric Modulated Arc (Radio) Therapy in Pets Treatment: The “La Cittadina Fondazione” Experience
by Mario Dolera, Luca Malfassi, Nancy Carrara, Sara Finesso, Silvia Marcarini, Giovanni Mazza, Simone Pavesi, Massimo Sala and Gaetano Urso
Cancers 2018, 10(2), 30; https://doi.org/10.3390/cancers10020030 - 24 Jan 2018
Cited by 3 | Viewed by 3772
Abstract
Volumetric Modulated Arc Therapy (VMAT) is a modern technique, widely used in human radiotherapy, which allows a high dose to be delivered to tumor volumes and low doses to the surrounding organs at risk (OAR). Veterinary clinics takes advantage of this feature due [...] Read more.
Volumetric Modulated Arc Therapy (VMAT) is a modern technique, widely used in human radiotherapy, which allows a high dose to be delivered to tumor volumes and low doses to the surrounding organs at risk (OAR). Veterinary clinics takes advantage of this feature due to the small target volumes and distances between the target and the OAR. Sparing the OAR permits dose escalation, and hypofractionation regimens reduce the number of treatment sessions with a simpler manageability in the veterinary field. Multimodal volumes definition is mandatory for the small volumes involved and a positioning device precisely reproducible with a setup confirmation is needed before each session for avoiding missing the target. Additionally, the elaborate treatment plan must pursue hard constraints and objectives, and its feasibility must be evaluated with a per patient quality control. The aim of this work is to report results with regard to brain meningiomas and gliomas, trigeminal nerve tumors, brachial plexus tumors, adrenal tumors with vascular invasion and rabbit thymomas, in comparison with literature to determine if VMAT is a safe and viable alternative to surgery or chemotherapy alone, or as an adjuvant therapy in pets. Full article
(This article belongs to the Special Issue Intensity Modulated Radiation Therapy)
731 KiB  
Review
Can Intensity-Modulated-Radiotherapy Reduce Toxicity in Head and Neck Squamous Cell Carcinoma?
by Julie Van der Veen and Sandra Nuyts
Cancers 2017, 9(10), 135; https://doi.org/10.3390/cancers9100135 - 06 Oct 2017
Cited by 45 | Viewed by 8934
Abstract
Intensity modulated radiotherapy (IMRT) is a modern radiotherapy technique that was implemented in the mid-1990s. It allows closer shaping of dose, to target volumes, thereby sparing organs at risk (OARs). Before the IMRT-era, two-dimensional radiotherapy (2DRT) and later three-dimensional conformal radiotherapy (3DCRT) were [...] Read more.
Intensity modulated radiotherapy (IMRT) is a modern radiotherapy technique that was implemented in the mid-1990s. It allows closer shaping of dose, to target volumes, thereby sparing organs at risk (OARs). Before the IMRT-era, two-dimensional radiotherapy (2DRT) and later three-dimensional conformal radiotherapy (3DCRT) were the techniques of choice, but this robust way of irradiating caused more normal tissue to receive a higher dose. Radiation of cancers in the head and neck region is complex because of close proximity to critical normal tissue and the large target volumes that need to be treated at high doses. IMRT offers an elegant solution compared with 3DCRT and surgery because it allows organ preservation and improved function preservation. In this manuscript, we review the rationales for IMRT, with an emphasis on toxicity outcomes compared with 3DCRT. We performed a review of the literature and looked at the most important randomised controlled trials comparing IMRT with 3DCRT. We conclude that IMRT is safe in regard to disease outcome, and that it allows better sparing of normal tissue, thereby causing less toxicity, resulting in a smaller impact on quality of life compared with conventional radiotherapy in the treatment of head and neck cancer. Full article
(This article belongs to the Special Issue Intensity Modulated Radiation Therapy)
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