Organocatalysts for Asymmetric Synthesis

A special issue of Catalysts (ISSN 2073-4344).

Deadline for manuscript submissions: closed (31 May 2019) | Viewed by 3193

Special Issue Editor

Muroran Inst Technol, 27-1 Mizumoto Cho, Muroran, Hokkaido 0508585, Japan
Interests: Chiral Catalyst; Asymmetric Synthesis; Drug Discovery; Chirality

Special Issue Information

Dear Colleagues,

Organocatalysis has developed into one of the most exciting and rapidly growing fields in organic chemistry from the last two decades. Particularly, asymmetric organocatalyzed synthesis has been intensively investigated areas in synthetic organic chemistry. Although biocatalysts, metal catalysts and organocatalysts are considered to be the three major pillars for modern asymmetric synthesis, organocatalysts has proved to be the most effective and attractive one, because it does not involve either toxic metals or expensive biocatalysts to carry out stereoselective transformations.

This Special Issue aims to cover recent progress and advances in the field of organocatalysts for asymmetric synthesis. This includes the design and synthesis of organocatalysts, their applications in the development of new asymmetric methodologies, and the synthesis of relevant chemicals, such as natural products, active pharmaceutical ingredients and innovative materials.

Prof. Hiroto Nakano
Guest Editor

Manuscript Submission Information

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Keywords

  • Organocatalysts
  • Asymmetric Synthesis
  • Enantioselectivity
  • Mechanisms
  • C-C bond formation
  • C-heteroatom bond formation

Published Papers (1 paper)

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Research

8 pages, 1072 KiB  
Article
Tripeptide-Catalyzed Asymmetric Aldol Reaction Between α-ketoesters and Acetone Under Acidic Cocatalyst-Free Conditions
by Kazumasa Kon, Hiromu Takai, Yoshihito Kohari and Miki Murata
Catalysts 2019, 9(6), 514; https://doi.org/10.3390/catal9060514 - 09 Jun 2019
Cited by 4 | Viewed by 2754
Abstract
Here, we report the tripeptide-catalyzed asymmetric aldol reaction between α-ketoesters and acetone under acidic cocatalysts-free conditions. H-Pro-Tle-Gly-OH 3g-catalyzed reactions between α-ketoesters and acetone resulted in up to 95% yield and 88% ee. Analysis of the transition state using density functional theory (DFT) [...] Read more.
Here, we report the tripeptide-catalyzed asymmetric aldol reaction between α-ketoesters and acetone under acidic cocatalysts-free conditions. H-Pro-Tle-Gly-OH 3g-catalyzed reactions between α-ketoesters and acetone resulted in up to 95% yield and 88% ee. Analysis of the transition state using density functional theory (DFT) calculations revealed that the tert-butyl group in 3g played an important role in enantioselectivity. Full article
(This article belongs to the Special Issue Organocatalysts for Asymmetric Synthesis)
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