Special Issue "Mitochondrial Bioenergetics in Cancer Cell Biology"

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 10 April 2018

Special Issue Editors

Guest Editor
Prof. Dr. Alessandra Baracca

Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum University of Bologna, 40126 Bologna, Italy
Website | E-Mail
Interests: cancer; metabolism; mitochondria; oxidative phosphorylation; ATP synthase; inhibitor protein IF1; hypoxia
Guest Editor
Prof. Dr. Giancarlo Solaini

Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum University of Bologna, 40126 Bologna, Italy
Website | E-Mail
Interests: cancer; bioenergetics; mitochondria; hypoxia; ischemia/reperfusion; ATP synthase; inhibitor protein IF1; ROS; antioxidant molecules

Special Issue Information

Dear Colleagues,

Mitochondria are essential organelles in mammalian cells and play a key role in many processes, including oxidative phosphorylation (OXPHOS), aerobic metabolism of glucose, amino acids, and fatty acids, calcium and reactive oxygen species (ROS) homeostasis and signaling, and apoptosis. Tumor cells exhibit profound genetic, biochemical and histological differences compared to non-transformed cellular types. Many tumor cells predominantly convert glucose to lactate to generate Adenosine 5’-triphosphate (ATP) and biomass; however, glycolysis becomes the main metabolic pathway for the cell energy supply when mitochondria are impaired or when cells experience hypoxic conditions. Nonetheless, many evidence indicate the essential need of functioning mitochondria for tumor cells survival and tumor propagation.

Cancer cells have to acquire a flexible and variable metabolism to face and survive the many stress conditions such as hypoxia, low glucose and other nutrients deficiency, exposure to low pH and high ROS levels. Therefore, tumor cells have to reprogramme their metabolism at many levels and mitochondria take a pivotal part in this task, thus becoming essential to driving disease progression.

The aim of this Special Issue of Cells is to collect and publish high quality original papers, research communications, and reviews exploring the involvement of mitochondria in cancer cells metabolism adaptation particularly focusing on bioenergetics.

Prof. Dr. Alessandra Baracca
Prof. Dr. Giancarlo Solaini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • transport
  • oxidative phosphorylation
  • respiratory chain complexes
  • ATP synthase
  • reactive oxygen/nitrogen species
  • redox biology
  • metabolism reprogramming
  • metabolism regulation
  • aminoacids metabolism
  • fatty acids metabolism
  • pyruvate/lactate metabolism
  • hypoxia
  • mitochondria-related signaling pathway
  • tumor
  • anti-tumor drug

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

1. Author: Ferdinando Chiaradonna
Affiliation: Università degli Studi di Milano-Bicocca | UNIMIB · Department of Biotechnology and Biosciences,Italy
Tentative title: HBP integrates nutrient availability with cell bioenergetics by regulating transcriptionally and post-transcriptionally key processes associated with cellular metabolism

2. Author: Zhang li
Affiliation: The Cecil H. and Ida Green Distinguished Chair of Systems Biology, The School of Natural Sciences and Mathematics,University of Texas at Dallas, USA
Tentative title: Mitochondrial respiration and heme function play crucial roles in lung tumor development and progression

3. Author: Laurent Schwartz
Affiliation: Hôpitaux de Paris | AP-HP la liberté a un prix et il est élevé, USA
Tentative title: A new anti- cancer agent targetting the mitochondria, chlorine dioxide

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