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Transient Receptor Potential (TRP) Channels
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Transient Receptor Potential (TRP) Channels

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: closed (28 February 2014) | Viewed by 163234

Special Issue Editor

Dr. Loren W. Runnels

E-Mail Website
Guest Editor
Department of Pharmacology, Rutgers Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
Interests: TRPM6 and TRPM7 ion channels; cell migration; development

Special Issue Information

Dear Colleagues,

Since the original cloning of the transient receptor potential (TRP) ion channel by Montell and Rubin in Drosophila melanogaster in 1989, the TRP ion channel family has grown to encompass seven subfamilies linked together primarily by their sequence homology: TRPC (“canonical”), TRPM (“melastatin”), TRPV (“vanilloid”), TRPA (“ankyrin”), TRPML (“mucolipin”), TRPP (or PKD for “polycystin”), and TRPN (“NOMPC-like”), which is only found in invertebrates and fish. TRP ion channels are widely expressed in many tissues and cell types, and have been shown to affect a broad range of cellular processes, including cell division, cell migration, and stress responses. These ion channels are also involved in the ability of cells to sense and respond to external stimuli, such as temperature, pH, and osmolarity. When activated, most TRP channels conduct cations to depolarize cells, so as to initiate a plethora of cellular responses. However, recent research has revealed important new functions for TRP ion channels in intracellular compartments. This Special Issue will provide an opportunity to publish open access research work and review articles related to the TRP channel family, and will offer comprehensive new insights into current developments within this exciting and important research field.

Dr. Loren W. Runnels
Guest Editor

Manuscript Submission Information

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Keywords

  • TRP
  • ion channel
  • calcium
  • magnesium
  • zinc
  • cellular regulation
  • signal transduction
  • development

Published Papers (16 papers)

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Research

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412 KiB  
Article
Unique Responses are Observed in Transient Receptor Potential Ankyrin 1 and Vanilloid 1 (TRPA1 and TRPV1) Co-Expressing Cells
by Laura R. Sadofsky, Koti T. Sreekrishna, Yakang Lin, Renee Schinaman, Kate Gorka, Yogita Mantri, John Christian Haught, Thomas G. Huggins, Robert J. Isfort, Charles C. Bascom and Alyn H. Morice
Cells 2014, 3(2), 616-626; https://doi.org/10.3390/cells3020616 - 11 Jun 2014
Cited by 28 | Viewed by 7847 | Correction
Abstract
Transient receptor potential (TRP) ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) receptors are implicated in modulation of cough and nociception. In vivo, TRPA1 and TRPV1 are often co-expressed in neurons and TRPA1V1 hetero-tetramer formation is noted in cells co-transfected with the respective [...] Read more.
Transient receptor potential (TRP) ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) receptors are implicated in modulation of cough and nociception. In vivo, TRPA1 and TRPV1 are often co-expressed in neurons and TRPA1V1 hetero-tetramer formation is noted in cells co-transfected with the respective expression plasmids. In order to understand the impact of TRP receptor interaction on activity, we created stable cell lines expressing the TRPA1, TRPV1 and co-expressing the TRPA1 and TRPV1 (TRPA1V1) receptors. Among the 600 compounds screened against these receptors, we observed a number of compounds that activated the TRPA1, TRPV1 and TRPA1V1 receptors; compounds that activated TRPA1 and TRPA1V1; compounds that activated TRPV1 and TRPA1V1; compounds in which TRPA1V1 response was modulated by either TRPA1 or TRPV1; and compounds that activated only TRPV1 or TRPA1 or TRPA1V1; and one compound that activated TRPA1 and TRPV1, but not TRPA1V1. These results suggest that co-expression of TRPA1 and TRPV1 receptors imparts unique activation profiles different from that of cells expressing only TRPA1 or TRPV1. Full article
(This article belongs to the Special Issue Transient Receptor Potential (TRP) Channels)
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1463 KiB  
Article
Aberrantly Over-Expressed TRPM8 Channels in Pancreatic Adenocarcinoma: Correlation with Tumor Size/Stage and Requirement for Cancer Cells Invasion
by Nelson S. Yee, Qin Li, Abid A. Kazi, Zhaohai Yang, Arthur Berg and Rosemary K. Yee
Cells 2014, 3(2), 500-516; https://doi.org/10.3390/cells3020500 - 23 May 2014
Cited by 23 | Viewed by 10713
Abstract
The transient receptor potential melastatin-subfamily member 8 (TRPM8) channels control Ca2+ homeostasis. Recent studies indicate that TRPM8 channels are aberrantly expressed and required for cellular proliferation in pancreatic adenocarcinoma. However, the functional significance of TRPM8 in pancreatic tissues is mostly unknown. The [...] Read more.
The transient receptor potential melastatin-subfamily member 8 (TRPM8) channels control Ca2+ homeostasis. Recent studies indicate that TRPM8 channels are aberrantly expressed and required for cellular proliferation in pancreatic adenocarcinoma. However, the functional significance of TRPM8 in pancreatic tissues is mostly unknown. The objectives of this study are to examine the expression of TRPM8 in various histopathological types of pancreatic tissues, determine its clinical significance in pancreatic adenocarcinoma, and investigate its functional role in cancer cells invasion. We present evidence that, in normal pancreatic tissues, anti-TRPM8 immunoreactivity is detected in the centroacinar cells and the islet endocrine cells. In pre-malignant pancreatic tissues and malignant neoplasms, TRPM8 is aberrantly expressed to variable extents. In the majority of pancreatic adenocarcinoma, TRPM8 is expressed at moderate or high levels, and anti-TRPM8 immunoreactivity positively correlates with the primary tumor size and stage. In the pancreatic adenocarcinoma cell lines that express relatively high levels of TRPM8, short hairpin RNA-mediated interference of TRPM8 expression impaired their ability of invasion. These data suggest that aberrantly expressed TRPM8 channels play contributory roles in pancreatic tumor growth and metastasis, and support exploration of TRPM8 as a biomarker and target of pancreatic adenocarcinoma. Full article
(This article belongs to the Special Issue Transient Receptor Potential (TRP) Channels)
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582 KiB  
Article
PKC-dependent Phosphorylation of the H1 Histamine Receptor Modulates TRPC6 Activity
by Xingjuan Chen, Christian Egly, Ashley M. Riley, Wennan Li, Paul Tewson, Thomas E. Hughes, Anne Marie Quinn and Alexander G. Obukhov
Cells 2014, 3(2), 247-257; https://doi.org/10.3390/cells3020247 - 04 Apr 2014
Cited by 16 | Viewed by 15330
Abstract
Transient receptor potential canonical 6 (TRPC6) is a cation selective, DAG-regulated, Ca2+-permeable channel activated by the agonists of Gq-protein-coupled heptahelical receptors. Dysfunctions of TRPC6 are implicated in the pathogenesis of various cardiovascular and kidney conditions such as vasospasm and [...] Read more.
Transient receptor potential canonical 6 (TRPC6) is a cation selective, DAG-regulated, Ca2+-permeable channel activated by the agonists of Gq-protein-coupled heptahelical receptors. Dysfunctions of TRPC6 are implicated in the pathogenesis of various cardiovascular and kidney conditions such as vasospasm and glomerulosclerosis. When stimulated by agonists of the histamine H1 receptor (H1R), TRPC6 activity decays to the baseline despite the continuous presence of the agonist. In this study, we examined whether H1R desensitization contributes to regulating the decay rate of TRPC6 activity upon receptor stimulation. We employed the HEK expression system and a biosensor allowing us to simultaneously detect the changes in intracellular diacylglycerol (DAG) and Ca2+ concentrations. We found that the histamine-induced DAG response was biphasic, in which a transient peak was followed by maintained elevated plateau, suggesting that desensitization of H1R takes place in the presence of histamine. The application of PKC inhibitor Gö6983 slowed the decay rate of intracellular DAG concentration. Activation of the mouse H1R mutant lacking a putative PKC phosphorylation site, Ser399, responsible for the receptor desensitization, resulted in a prolonged intracellular DAG increase and greater Mn2+ influx through the TRPC6 channel. Thus, our data support the hypothesis that PKC-dependent H1R phosphorylation leads to a reduced production of intracellular DAG that contributes to TRPC6 activity regulation. Full article
(This article belongs to the Special Issue Transient Receptor Potential (TRP) Channels)
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Review

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932 KiB  
Review
Natural and Synthetic Modulators of the TRPM7 Channel
by Vladimir Chubanov, Sebastian Schäfer, Silvia Ferioli and Thomas Gudermann
Cells 2014, 3(4), 1089-1101; https://doi.org/10.3390/cells3041089 - 27 Nov 2014
Cited by 46 | Viewed by 8856
Abstract
Transient receptor potential cation channel subfamily M member 7 (TRPM7) is a bi-functional protein comprising a TRP ion channel segment linked to an α-type protein kinase domain. Genetic inactivation of TRPM7 revealed its central role in magnesium metabolism, cell motility, proliferation and differentiation. [...] Read more.
Transient receptor potential cation channel subfamily M member 7 (TRPM7) is a bi-functional protein comprising a TRP ion channel segment linked to an α-type protein kinase domain. Genetic inactivation of TRPM7 revealed its central role in magnesium metabolism, cell motility, proliferation and differentiation. TRPM7 is associated with anoxic neuronal death, cardiac fibrosis and tumor progression highlighting TRPM7 as a new drug target. Recently, several laboratories have independently identified pharmacological compounds inhibiting or activating the TRPM7 channel. The recently found TRPM7 modulators were used as new experimental tools to unravel cellular functions of the TRPM7 channel. Here, we provide a concise overview of this emerging field. Full article
(This article belongs to the Special Issue Transient Receptor Potential (TRP) Channels)
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1788 KiB  
Review
Classical Transient Receptor Potential 1 (TRPC1): Channel or Channel Regulator?
by Alexander Dietrich, Meike Fahlbusch and Thomas Gudermann
Cells 2014, 3(4), 939-962; https://doi.org/10.3390/cells3040939 - 29 Sep 2014
Cited by 67 | Viewed by 10425
Abstract
In contrast to other Classical Transient Receptor Potential TRPC channels the function of TRPC1 as an ion channel is a matter of debate, because it is often difficult to obtain substantial functional signals over background in response to over-expression of TRPC1 alone. Along [...] Read more.
In contrast to other Classical Transient Receptor Potential TRPC channels the function of TRPC1 as an ion channel is a matter of debate, because it is often difficult to obtain substantial functional signals over background in response to over-expression of TRPC1 alone. Along these lines, heterologously expressed TRPC1 is poorly translocated to the plasma membrane as a homotetramer and may not function on its own physiologically, but may rather be an important linker and regulator protein in heteromeric TRPC channel tetramers. However, due to the lack of specific TRPC1 antibodies able to detect native TRPC1 channels in primary cells, identification of functional TRPC1 containing heteromeric TRPC channel complexes in the plasma membrane is still challenging. Moreover, an extended TRPC1 cDNA, which was recently discovered, may seriously question results obtained in heterologous expression systems transfected with shortened cDNA versions. Therefore, this review will focus on the current status of research on TRPC1 function obtained in primary cells and a TRPC1-deficient mouse model. Full article
(This article belongs to the Special Issue Transient Receptor Potential (TRP) Channels)
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1231 KiB  
Review
TRPV1 and Endocannabinoids: Emerging Molecular Signals that Modulate Mammalian Vision
by Daniel A. Ryskamp, Sarah Redmon, Andrew O. Jo and David Križaj
Cells 2014, 3(3), 914-938; https://doi.org/10.3390/cells3030914 - 12 Sep 2014
Cited by 52 | Viewed by 12288
Abstract
Transient Receptor Potential Vanilloid 1 (TRPV1) subunits form a polymodal cation channel responsive to capsaicin, heat, acidity and endogenous metabolites of polyunsaturated fatty acids. While originally reported to serve as a pain and heat detector in the peripheral nervous system, TRPV1 has been [...] Read more.
Transient Receptor Potential Vanilloid 1 (TRPV1) subunits form a polymodal cation channel responsive to capsaicin, heat, acidity and endogenous metabolites of polyunsaturated fatty acids. While originally reported to serve as a pain and heat detector in the peripheral nervous system, TRPV1 has been implicated in the modulation of blood flow and osmoregulation but also neurotransmission, postsynaptic neuronal excitability and synaptic plasticity within the central nervous system. In addition to its central role in nociception, evidence is accumulating that TRPV1 contributes to stimulus transduction and/or processing in other sensory modalities, including thermosensation, mechanotransduction and vision. For example, TRPV1, in conjunction with intrinsic cannabinoid signaling, might contribute to retinal ganglion cell (RGC) axonal transport and excitability, cytokine release from microglial cells and regulation of retinal vasculature. While excessive TRPV1 activity was proposed to induce RGC excitotoxicity, physiological TRPV1 activity might serve a neuroprotective function within the complex context of retinal endocannabinoid signaling. In this review we evaluate the current evidence for localization and function of TRPV1 channels within the mammalian retina and explore the potential interaction of this intriguing nociceptor with endogenous agonists and modulators. Full article
(This article belongs to the Special Issue Transient Receptor Potential (TRP) Channels)
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1104 KiB  
Review
Cellular and Developmental Biology of TRPM7 Channel-Kinase: Implicated Roles in Cancer
by Nelson S. Yee, Abid A. Kazi and Rosemary K. Yee
Cells 2014, 3(3), 751-777; https://doi.org/10.3390/cells3030751 - 30 Jul 2014
Cited by 45 | Viewed by 10012
Abstract
The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously expressed cation-permeable ion channel with intrinsic kinase activity that plays important roles in various physiological functions. Biochemical and electrophysiological studies, in combination with molecular analyses of TRPM7, have generated insights into its [...] Read more.
The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously expressed cation-permeable ion channel with intrinsic kinase activity that plays important roles in various physiological functions. Biochemical and electrophysiological studies, in combination with molecular analyses of TRPM7, have generated insights into its functions as a cellular sensor and transducer of physicochemical stimuli. Accumulating evidence indicates that TRPM7 channel-kinase is essential for cellular processes, such as proliferation, survival, differentiation, growth, and migration. Experimental studies in model organisms, such as zebrafish, mouse, and frog, have begun to elucidate the pleiotropic roles of TRPM7 during embryonic development from gastrulation to organogenesis. Aberrant expression and/or activity of the TRPM7 channel-kinase have been implicated in human diseases including a variety of cancer. Studying the functional roles of TRPM7 and the underlying mechanisms in normal cells and developmental processes is expected to help understand how TRPM7 channel-kinase contributes to pathogenesis, such as malignant neoplasia. On the other hand, studies of TRPM7 in diseases, particularly cancer, will help shed new light in the normal functions of TRPM7 under physiological conditions. In this article, we will provide an updated review of the structural features and biological functions of TRPM7, present a summary of current knowledge of its roles in development and cancer, and discuss the potential of TRPM7 as a clinical biomarker and therapeutic target in malignant diseases. Full article
(This article belongs to the Special Issue Transient Receptor Potential (TRP) Channels)
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409 KiB  
Review
TRPV Channels in Mast Cells as a Target for Low-Level-Laser Therapy
by Lina Wang, Di Zhang and Wolfgang Schwarz
Cells 2014, 3(3), 662-673; https://doi.org/10.3390/cells3030662 - 26 Jun 2014
Cited by 39 | Viewed by 7770
Abstract
Low-level laser irradiation in the visible as well as infrared range is applied to skin for treatment of various diseases. Here we summarize and discuss effects of laser irradiation on mast cells that leads to degranulation of the cells. This process may contribute [...] Read more.
Low-level laser irradiation in the visible as well as infrared range is applied to skin for treatment of various diseases. Here we summarize and discuss effects of laser irradiation on mast cells that leads to degranulation of the cells. This process may contribute to initial steps in the final medical effects. We suggest that activation of TRPV channels in the mast cells forms a basis for the underlying mechanisms and that released ATP and histamine may be putative mediators for therapeutic effects. Full article
(This article belongs to the Special Issue Transient Receptor Potential (TRP) Channels)
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657 KiB  
Review
TRPV1: A Potential Drug Target for Treating Various Diseases
by Rafael Brito, Sandeep Sheth, Debashree Mukherjea, Leonard P. Rybak and Vickram Ramkumar
Cells 2014, 3(2), 517-545; https://doi.org/10.3390/cells3020517 - 23 May 2014
Cited by 105 | Viewed by 12886
Abstract
Transient receptor potential vanilloid 1 (TRPV1) is an ion channel present on sensory neurons which is activated by heat, protons, capsaicin and a variety of endogenous lipids termed endovanilloids. As such, TRPV1 serves as a multimodal sensor of noxious stimuli which could trigger [...] Read more.
Transient receptor potential vanilloid 1 (TRPV1) is an ion channel present on sensory neurons which is activated by heat, protons, capsaicin and a variety of endogenous lipids termed endovanilloids. As such, TRPV1 serves as a multimodal sensor of noxious stimuli which could trigger counteractive measures to avoid pain and injury. Activation of TRPV1 has been linked to chronic inflammatory pain conditions and peripheral neuropathy, as observed in diabetes. Expression of TRPV1 is also observed in non-neuronal sites such as the epithelium of bladder and lungs and in hair cells of the cochlea. At these sites, activation of TRPV1 has been implicated in the pathophysiology of diseases such as cystitis, asthma and hearing loss. Therefore, drugs which could modulate TRPV1 channel activity could be useful for the treatment of conditions ranging from chronic pain to hearing loss. This review describes the roles of TRPV1 in the normal physiology and pathophysiology of selected organs of the body and highlights how drugs targeting this channel could be important clinically. Full article
(This article belongs to the Special Issue Transient Receptor Potential (TRP) Channels)
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387 KiB  
Review
Physiological Function and Characterization of TRPCs in Neurons
by Yuyang Sun, Pramod Sukumaran, Bidhan C. Bandyopadhyay and Brij B. Singh
Cells 2014, 3(2), 455-475; https://doi.org/10.3390/cells3020455 - 21 May 2014
Cited by 27 | Viewed by 10142
Abstract
Ca2+ entry is essential for regulating vital physiological functions in all neuronal cells. Although neurons are engaged in multiple modes of Ca2+ entry that regulates variety of neuronal functions, we will only discuss a subset of specialized Ca2+-permeable non-selective [...] Read more.
Ca2+ entry is essential for regulating vital physiological functions in all neuronal cells. Although neurons are engaged in multiple modes of Ca2+ entry that regulates variety of neuronal functions, we will only discuss a subset of specialized Ca2+-permeable non-selective Transient Receptor Potential Canonical (TRPC) channels and summarize their physiological and pathological role in these excitable cells. Depletion of endoplasmic reticulum (ER) Ca2+ stores, due to G-protein coupled receptor activation, has been shown to activate TRPC channels in both excitable and non-excitable cells. While all seven members of TRPC channels are predominately expressed in neuronal cells, the ion channel properties, mode of activation, and their physiological responses are quite distinct. Moreover, many of these TRPC channels have also been suggested to be associated with neuronal development, proliferation and differentiation. In addition, TRPCs also regulate neurosecretion, long-term potentiation and synaptic plasticity. Similarly, perturbations in Ca2+ entry via the TRPC channels have been also suggested in a spectrum of neuropathological conditions. Hence, understanding the precise involvement of TRPCs in neuronal function and in neurodegenerative conditions would presumably unveil avenues for plausible therapeutic interventions for these devastating neuronal diseases. Full article
(This article belongs to the Special Issue Transient Receptor Potential (TRP) Channels)
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2462 KiB  
Review
TRP Channels Involved in Spontaneous L-Glutamate Release Enhancement in the Adult Rat Spinal Substantia Gelatinosa
by Eiichi Kumamoto, Tsugumi Fujita and Chang-Yu Jiang
Cells 2014, 3(2), 331-362; https://doi.org/10.3390/cells3020331 - 29 Apr 2014
Cited by 24 | Viewed by 19194
Abstract
The spinal substantia gelatinosa (SG) plays a pivotal role in modulating nociceptive transmission through dorsal root ganglion (DRG) neurons from the periphery. TRP channels such as TRPV1 and TRPA1 channels expressed in the SG are involved in the regulation of the nociceptive transmission. [...] Read more.
The spinal substantia gelatinosa (SG) plays a pivotal role in modulating nociceptive transmission through dorsal root ganglion (DRG) neurons from the periphery. TRP channels such as TRPV1 and TRPA1 channels expressed in the SG are involved in the regulation of the nociceptive transmission. On the other hand, the TRP channels located in the peripheral terminals of the DRG neurons are activated by nociceptive stimuli given to the periphery and also by plant-derived chemicals, which generates a membrane depolarization. The chemicals also activate the TRP channels in the SG. In this review, we introduce how synaptic transmissions in the SG neurons are affected by various plant-derived chemicals and suggest that the peripheral and central TRP channels may differ in property from each other. Full article
(This article belongs to the Special Issue Transient Receptor Potential (TRP) Channels)
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658 KiB  
Review
The Role of Canonical Transient Receptor Potential Channels in Seizure and Excitotoxicity
by Fang Zheng and Kevin D. Phelan
Cells 2014, 3(2), 288-303; https://doi.org/10.3390/cells3020288 - 09 Apr 2014
Cited by 30 | Viewed by 8550
Abstract
Canonical transient receptor potential (TRPC) channels are a family of polymodal cation channels with some degree of Ca2+ permeability. Although initially thought to be channels mediating store-operated Ca2+ influx, TRPC channels can be activated by stimulation of Gq-coupled G-protein coupled receptors, [...] Read more.
Canonical transient receptor potential (TRPC) channels are a family of polymodal cation channels with some degree of Ca2+ permeability. Although initially thought to be channels mediating store-operated Ca2+ influx, TRPC channels can be activated by stimulation of Gq-coupled G-protein coupled receptors, or by an increase in intracellular free Ca2+ concentration. Thus, activation of TRPC channels could be a common downstream event of many signaling pathways that contribute to seizure and excitotoxicity, such as N-methyl-D-aspartate (NMDA) receptor-mediated Ca2+ influx, or metabotropic glutamate receptor activation. Recent studies with genetic ablation of various TRPC family members have demonstrated that TRPC channels, in particular heteromeric TRPC1/4 channels and homomeric TRPC5 channels, play a critical role in both pilocarpine-induced acute seizures and neuronal cell death. However, exact underlying mechanisms remain to be fully elucidated, and selective TRPC modulators and antibodies with better specificity are urgently needed for future research. Full article
(This article belongs to the Special Issue Transient Receptor Potential (TRP) Channels)
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1325 KiB  
Review
Post-Translational Modifications of TRP Channels
by Olaf Voolstra and Armin Huber
Cells 2014, 3(2), 258-287; https://doi.org/10.3390/cells3020258 - 08 Apr 2014
Cited by 41 | Viewed by 9573
Abstract
Transient receptor potential (TRP) channels constitute an ancient family of cation channels that have been found in many eukaryotic organisms from yeast to human. TRP channels exert a multitude of physiological functions ranging from Ca2+ homeostasis in the kidney to pain reception [...] Read more.
Transient receptor potential (TRP) channels constitute an ancient family of cation channels that have been found in many eukaryotic organisms from yeast to human. TRP channels exert a multitude of physiological functions ranging from Ca2+ homeostasis in the kidney to pain reception and vision. These channels are activated by a wide range of stimuli and undergo covalent post-translational modifications that affect and modulate their subcellular targeting, their biophysical properties, or channel gating. These modifications include N-linked glycosylation, protein phosphorylation, and covalent attachment of chemicals that reversibly bind to specific cysteine residues. The latter modification represents an unusual activation mechanism of ligand-gated ion channels that is in contrast to the lock-and-key paradigm of receptor activation by its agonists. In this review, we summarize the post-translational modifications identified on TRP channels and, when available, explain their physiological role. Full article
(This article belongs to the Special Issue Transient Receptor Potential (TRP) Channels)
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297 KiB  
Review
Loss of TRPV2 Homeostatic Control of Cell Proliferation Drives Tumor Progression
by Sonia Liberati, Maria Beatrice Morelli, Consuelo Amantini, Valerio Farfariello, Matteo Santoni, Alessandro Conti, Massimo Nabissi, Stefano Cascinu and Giorgio Santoni
Cells 2014, 3(1), 112-128; https://doi.org/10.3390/cells3010112 - 19 Feb 2014
Cited by 44 | Viewed by 8219 | Correction
Abstract
Herein we evaluate the involvement of the TRPV2 channel, belonging to the Transient Receptor Potential Vanilloid channel family (TRPVs), in development and progression of different tumor types. In normal cells, the activation of TRPV2 channels by growth factors, hormones, and endocannabinoids induces a [...] Read more.
Herein we evaluate the involvement of the TRPV2 channel, belonging to the Transient Receptor Potential Vanilloid channel family (TRPVs), in development and progression of different tumor types. In normal cells, the activation of TRPV2 channels by growth factors, hormones, and endocannabinoids induces a translocation of the receptor from the endosomal compartment to the plasma membrane, which results in abrogation of cell proliferation and induction of cell death. Consequently, loss or inactivation of TRPV2 signaling (e.g., glioblastomas), induces unchecked proliferation, resistance to apoptotic signals and increased resistance to CD95-induced apoptotic cell death. On the other hand, in prostate cancer cells, Ca2+-dependent activation of TRPV2 induced by lysophospholipids increases the invasion of tumor cells. In addition, the progression of prostate cancer to the castration-resistant phenotype is characterized by de novo TRPV2 expression, with higher TRPV2 transcript levels in patients with metastatic cancer. Finally, TRPV2 functional expression in tumor cells can also depend on the presence of alternative splice variants of TRPV2 mRNA that act as dominant-negative mutant of wild-type TRPV2 channels, by inhibiting its trafficking and translocation to the plasma membrane. In conclusion, as TRP channels are altered in human cancers, and their blockage impair tumor progression, they appear to be a very promising targets for early diagnosis and chemotherapy. Full article
(This article belongs to the Special Issue Transient Receptor Potential (TRP) Channels)
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594 KiB  
Correction
Correction: Sadofsky, L.R., et al. Unique Responses are Observed in Transient Receptor Potential Ankyrin 1 and Vanilloid 1 (TRPA1 and TRPV1) Co-Expressing Cells. Cells 2014, 3, 616-626
by Laura R. Sadofsky, Koti T. Sreekrishna, Yakang Lin, Renee Schinaman, Kate Gorka, Yogita Mantri, John Christian Haught, Thomas G. Huggins, Robert J. Isfort, Charles C. Bascom and Alyn H. Morice
Cells 2014, 3(4), 994-995; https://doi.org/10.3390/cells3040994 - 27 Oct 2014
Viewed by 4631
Abstract
The authors wish to make the following corrections to this paper [1]: In Table 2 on page 623, the Quercinitol activation value for TRPA1V1 should be 2.3 instead of 57.6. Quercinitol does not activate TRPA1V1. We thank Michael J.M. Fisher (University of Erlangen, [...] Read more.
The authors wish to make the following corrections to this paper [1]: In Table 2 on page 623, the Quercinitol activation value for TRPA1V1 should be 2.3 instead of 57.6. Quercinitol does not activate TRPA1V1. We thank Michael J.M. Fisher (University of Erlangen, Germany) for his feedback which helped us to review our result. The authors would like to apologize for any inconvenience caused to the readers by these changes. Full article
(This article belongs to the Special Issue Transient Receptor Potential (TRP) Channels)
113 KiB  
Correction
Correction: Liberati, S., et al. Loss of TRPV2 Homeostatic Control of Cell Proliferation Drives Tumor Progression. Cells 2014, 3, 112–128
by Sonia Liberati, Maria Beatrice Morelli, Consuelo Amantini, Valerio Farfariello, Matteo Santoni, Alessandro Conti, Massimo Nabissi, Stefano Cascinu and Giorgio Santoni
Cells 2014, 3(2), 660-661; https://doi.org/10.3390/cells3020660 - 20 Jun 2014
Cited by 8 | Viewed by 5044
Abstract
The authors wish to make the following corrections to this paper [1]: [...] Full article
(This article belongs to the Special Issue Transient Receptor Potential (TRP) Channels)
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