Special Issue "Beyond Cell Mechanics: Novel Functions of Intermediate Filaments"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (20 February 2016)
The compositional diversity of cytoplasmic intermediate filaments supports cell type-specific function in metazoan cells. Besides providing a highly adaptable mechanical scaffold that is anchored to neighboring cells and the extracellular matrix, intermediate filaments support many cellular processes. These include signaling, gene regulation, vesicle trafficking, mitochondrial function, and cell fate determination. Intermediate filaments are also involved in pathologies, such as inflammation, organ-specific diseases, and cancer. It is a common belief that the abundance of intermediate filaments makes them an ideal buffer system for protecting cells against any kind of insult, be it physical, chemical or microbial.
Challenging questions that we currently face include:
- How do intermediate filament mechanics affect cell function?
- How can we measure and examine the consequences of minor changes in low affinity interactions of intermediate filaments in the context of long-term tissue function?
- How do cytoplasmic intermediate filaments integrate tissue function?
- What are the molecular mechanisms that determine isotype-specific intermediate filament functions?
This current volume aims to present novel ideas and hypotheses as to intermediate filament function in specific cellular and tissue contexts.
Prof. Dr. Rudolf E. Leube
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- intermediate filaments
- vesicle trafficking
- mitochondrial function
- stress response