Special Issue "Signal Transduction 2016"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (30 November 2016)
Prof. Dr. Ritva Tikkanen
Institute of Biochemistry, Medical Faculty, Justus-Liebig University of Giessen, Friedrichstrasse 24, D-35392, Giessen, Germany
Website | E-Mail
Interests: signal transduction; receptor tyrosine kinases; mitogen-activated protein kinases; endosomal sorting; lysosome biogenesis; lysosomal storage diseases; cell adhesion; cell polarity
Signal transduction processes are of vital importance for the cell as they regulate a plethora of cellular processes, including growth, differentiation, and cell death. The importance of cellular signaling is highlighted by the fact that signaling errors, e.g., after a mutation of endogenous genes or upon impaired stimuli, are the reason for numerous human diseases. However, although signaling cascades are frequently depicted as linear “flow-charts”, the cellular reality is much more complicated, and the signaling pathways frequently crosstalk and interact. Thus, understanding the fine-tuning of signaling, and the networks of signaling molecules, will be a major task in the future. In this Special Issue, we are interested in manuscripts (e.g., reviews or original articles) that address various aspects of this important topic. We especially welcome manuscripts that focus on aberrant signaling, such as oncogenic signal transduction and networks, or crosstalk between signaling pathways. However, manuscripts about signaling in normal cells are also highly appreciated. We hope that this important topic will attract a large number of contributions from both basic and clinical scientists.
Prof. Dr. Ritva Tikkanen
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- signal transduction
- hormones, growth factors
- spatial and temporal signaling
- differentiation and growth
- signaling networks
- crosstalk and transactivation
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of the paper: Review
Tentative title: The Diverse Functions and Signal Transduction of the Exocyst Complex in Tumor Cells
Authors: Toshiaki Tanaka 1,2,*, Kaoru Goto 1, Mitsuyoshi Iino 2
Affiliations: 1 Department of Anatomy and Cell Biology, School of Medicine, Yamagata University, 2-2-2 Iidanishi, Yamagata, Japan; 2 Department of Dentistry, Oral and Maxillofacial Surgery, Plastic and Reconstructive Surgery, School of Medicine, Yamagata University, 2-2-2 Iidanishi, Yamagata, Japan; * Corresponding author.
Abstract: The exocyst complexes are the large conserved hetero-oligomeric complexes that consist of Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70, and Exo84.The exocyst complexes are implicated in the targeting of vesicles for regulated exocytosis in various cell types and important for targeted exocytosis of post-Golgi transport vesicles to the plasma membrane. The exocyst complexes are essential for membrane growth and secretion and function in exocytosis, endocytosis, cytokinesis, and autophagy. Therefore, recent studies indicated that the exocyst complexes may be involved in several diseases such as Meckel-Gruber syndrome, neuropathogenesis, diabetes, and cancers.In this review, we focus on the diverse functions and cellular signaling pathways in various tumors.
Tentative title: Role of Cytokines-Induced Glycosylation Changes in Regulating Cell Interactions and Cell Signaling
Authors: Justine H. Dewald, Florent Colomb, Marie Bobowski, Sophie Groux-Degroote, Philippe Delannoy
Abstract: Glycosylation is one of the most important modifications of proteins and lipids, and cell surface glycoconjugates are thought to play important roles in a variety of biological functions including cell–cell and cell-substrate interactions, bacterial adhesion, cell immunogenicity and cell signaling. Glycosylation alterations are observed in several diseases such as cancer and chronic inflammation. In that context, pro-inflammatory cytokines have been shown to regulate cell surface glycosylation by regulating the expression of glycosyltransferases involved in the biosynthesis of carbohydrate chains. These changes in cell surface glycosylation are also known to regulate cell signaling and could contribute to disease pathogenesis. This review summarizes our current knowledge of the glycosylation changes induced by pro-inflammatory cytokines, with a particular focus on cancer and chronic inflammation, and their consequences on cell interactions and signaling.