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Cells
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Sirtuins in Aging and Diseases
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Sirtuins in Aging and Diseases

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Motility and Adhesion".

Deadline for manuscript submissions: closed (15 December 2016) | Viewed by 11298

Special Issue Editor

Dr. Bor Luen Tang

E-Mail Website
Guest Editor
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Interests: membrane trafficking; neuronal death and regeneration; Sirt1 and aging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The class III histone deacetylases, or Sirtuins, has been a focal point of intense interest for many in the basic sciences and translational researches alike for the past 10-15 years. An involvement of Sirtuins has been found in a myriad of aspects of biomedical research, from the understanding of fundamental cellular processes to the validation of drug targets. Sirtuins’ association with cellular and systemic aging and organismal longevity, as well as their deciphered roles and identified substrates in homeostatic regulation of cell/tissue survival and energy metabolism have captured the attention and fascination of many.

In this Special Issue, we invite your contributions, either in the form of original research articles, reviews, or shorter “Perspective” articles on all aspects related to the theme of “Sirtuins in Aging and Diseases”. Articles with mechanistic and functional insights from a cell and molecular biological perspective are especially welcome.

Assoc. Prof. Bor Luen Tang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Aging
  • Cancer
  • Histone Deacetylase
  • Longevity
  • Metabolic regulation
  • Senescence
  • Sirt1
  • Sirtuins

Published Papers (2 papers)

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Research

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1909 KiB  
Article
Segmental Aging Underlies the Development of a Parkinson Phenotype in the AS/AGU Rat
by Sohair M. Khojah, Anthony P. Payne, Dagmara McGuinness and Paul G. Shiels
Cells 2016, 5(4), 38; https://doi.org/10.3390/cells5040038 - 17 Oct 2016
Cited by 11 | Viewed by 5576
Abstract
There is a paucity of information on the molecular biology of aging processes in the brain. We have used biomarkers of aging (SA β-Gal, p16Ink4a, Sirt5, Sirt6, and Sirt7) to demonstrate the presence of an accelerated aging phenotype across different brain [...] Read more.
There is a paucity of information on the molecular biology of aging processes in the brain. We have used biomarkers of aging (SA β-Gal, p16Ink4a, Sirt5, Sirt6, and Sirt7) to demonstrate the presence of an accelerated aging phenotype across different brain regions in the AS/AGU rat, a spontaneous Parkinsonian mutant of PKCγ derived from a parental AS strain. P16INK4a expression was significantly higher in AS/AGU animals compared to age-matched AS controls (p < 0.001) and displayed segmental expression across various brain regions. The age-related expression of sirtuins similarly showed differences between strains and between brain regions. Our data clearly show segmental aging processes within the rat brain, and that these are accelerated in the AS/AGU mutant. The accelerated aging, Parkinsonian phenotype, and disruption to dopamine signalling in the basal ganglia in AS/AGU rats, suggests that this rat strain represents a useful model for studies of development and progression of Parkinson’s disease in the context of biological aging and may offer unique mechanistic insights into the biology of aging. Full article
(This article belongs to the Special Issue Sirtuins in Aging and Diseases)
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Review

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Review
The Role and Application of Sirtuins and mTOR Signaling in the Control of Ovarian Functions
by Alexander V. Sirotkin
Cells 2016, 5(4), 42; https://doi.org/10.3390/cells5040042 - 24 Nov 2016
Cited by 30 | Viewed by 5240
Abstract
The present short review demonstrates the involvement of sirtuins (SIRTs) in the control of ovarian functions at various regulatory levels. External and endocrine factors can affect female reproduction via SIRTs-mammalian target of rapamycin (mTOR) system, which, via hormones and growth factors, can in [...] Read more.
The present short review demonstrates the involvement of sirtuins (SIRTs) in the control of ovarian functions at various regulatory levels. External and endocrine factors can affect female reproduction via SIRTs-mammalian target of rapamycin (mTOR) system, which, via hormones and growth factors, can in turn regulate basic ovarian functions (proliferation, apoptosis, secretory activity of ovarian cells, their response to upstream hormonal regulators, ovarian folliculo- and oogenesis, and fecundity). SIRTs and SIRTs-related signaling molecules and drugs regulating mTOR can be used for characterization, prediction, and regulation of ovarian functions, as well as for diagnostics and treatment of ovarian disorders. Full article
(This article belongs to the Special Issue Sirtuins in Aging and Diseases)
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