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Challenges
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Challenges in Urban Air Pollution and Respiratory Health
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Challenges in Urban Air Pollution and Respiratory Health

A special issue of Challenges (ISSN 2078-1547).

Deadline for manuscript submissions: closed (1 May 2013) | Viewed by 6031

Special Issue Editors

Prof. Dr. Andrij Holian

E-Mail Website
Guest Editor
Department of Biomedical and Pharmaceutical Sciences, University of Montana Missoula, Missoula, MT, USA
Interests: nanoparticles; particulate matter; asbestos; silica; alveolar macrophages; innate immunity; NLRP3 inflammasome; macrophage receptors; lysosomes
Special Issues, Collections and Topics in MDPI journals
Dr. Christopher Migliaccio

E-Mail Website
Guest Editor
Center for Environmental Health Sciences, University of Montana, Missoula, MT 59812, USA
Interests: respiratory immunity; fibrosis; inflammation; autoimmune diseases; particle exposures
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Many studies have documented the health effects of air toxics, priority air pollutant gases and particulates on human health. In addition studies have identified susceptible populations such as the young, elderly and those with compromised conditions (e.g. respiratory, cardiovascular). However, much of the information is descriptive and it remains uncertain how to evaluate contributions from a variety of sources when exposed to these complex mixtures. Of additional concern is the comparison of indoor versus outdoor exposures and their relative contributions to human health.

The purpose of this issue of Challenges is to advance the field of respiratory exposures and the impacts on individual and community health. The issue is designed to accomplish this through a multidisciplinary approach. Reviews of the current state of knowledge will be coupled with identification of emerging areas of concern. Additionally, economical interventions to protect the greatest number of susceptible individuals will be proposed and evaluated from multiple perspectives including, but not limited to biomedical, societal, atmospheric, and environmental.

Prof. Dr. Andrij Holian
Dr. Christopher Migliaccio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Challenges is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mixtures
  • sources
  • indoor/outdoor
  • mechanisms
  • human health
  • susceptible populations
  • economics
  • interventions

Published Papers (1 paper)

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Research

927 KiB  
Article
The Secretome of Human Bronchial Epithelial Cells Exposed to Fine Atmospheric Particles Induces Fibroblast Proliferation
by Laura Boublil, Laurent Martinon and Armelle Baeza-Squiban
Challenges 2013, 4(2), 188-200; https://doi.org/10.3390/challe4020188 - 30 Aug 2013
Cited by 1 | Viewed by 5630
Abstract
Chronic exposure to particulate pollution is suspected to exacerbate inflammatory respiratory diseases such as asthma characterized by an airway remodelling involving fibrosis. Our study aims to investigate whether the secretome from human bronchial epithelial (HBE) cells exposed to fine particulate matter (PM) induces [...] Read more.
Chronic exposure to particulate pollution is suspected to exacerbate inflammatory respiratory diseases such as asthma characterized by an airway remodelling involving fibrosis. Our study aims to investigate whether the secretome from human bronchial epithelial (HBE) cells exposed to fine particulate matter (PM) induces fibroblast proliferation. Primary HBE cells grown on air liquid interface were repeatedly exposed to fine PM at 5 and 10 µg/cm² (four treatments, 48 hours apart) and maintained in culture for five weeks. Collected basolateral culture medium was used as a conditioned medium for the subsequent treatment of fibroblasts. We observed that the conditioned medium collected from HBE cells treated with fine PM increased the growth rate of fibroblasts compared to the conditioned medium collected from control HBE cells. Fibroblast phenotype assessed by the observation of the vimentin network was well preserved. The mitogenic effect of conditioned medium was reduced in the presence of anti-epidermal growth factor receptor (EGFR), anti-amphiregulin or anti-TGFa, underlining the role of EGFR ligands in fibroblast proliferation. When fibroblasts were co-cultured with HBE cells treated once with fine PM, they exhibited a higher growth rate than fibroblasts co-cultured with non-treated HBE cells. Altogether these data show that the exposure of HBE cells to fine PM induced the production of EGFR ligands in sufficient amount to stimulate fibroblast proliferation providing insight into the role of PM in airway remodelling. Full article
(This article belongs to the Special Issue Challenges in Urban Air Pollution and Respiratory Health)
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