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Self-assembled Monolayers and Multilayers (SAMs/SAMTs) for Medicine and Dentistry

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A special issue of Coatings (ISSN 2079-6412).

Deadline for manuscript submissions: closed (15 October 2015) | Viewed by 45700

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Special Issue Editor

Dr. James Kit-Hon Tsoi

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Guest Editor

Dental Materials Science, Faculty of Dentistry, The University of Hong Kong, Sai Ying Pun, Hong Kong
Interests: dental materials; adhesion; titanium; implants; pharmaceutics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the years, nanotechnology has been vastly applied in medical and dental fields. In particular, self-assembled monolayers and multilayers (SAMs/SAMTs) have been put into services and have gained wide acceptance by practitioners and researchers due to several reasons, such as surface functionalization, ease of application, high biocompatibility, and simplicity. In this Special Issue, all review and research articles related to SAMs/SAMTs in medical and dental fields are welcomed. Emphasis should be put on, but not limited to, chemical, physical, biological, clinical, theoretical, and mechanical aspects, and multi-disciplinary approaches to SAMs/SAMTs. The Special Issue is keen on the exchange and sharing of scientific knowledge and evidence via the Open Access journal Coatings, and targets to sustain the impact of SAMs/SAMTs.

Dr. James Kit-hon Tsoi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Coatings is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

self-assembled monolayers (SAMs)
self-assembled multilayers (SAMTs)
biomaterials
nanocoatings
surface
functionalization
dental materials
medical materials
characterization

Published Papers (5 papers)

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Research

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3167 KiB

Open AccessArticle

Growth and Functionality of Cells Cultured on Conducting and Semi-Conducting Surfaces Modified with Self-Assembled Monolayers (SAMs)

by Rajendra K. Aithal, Amber T. Doss, Deepak P. Kumaraswamy, David K. Mills and Debasish Kuila

Coatings 2016, 6(1), 9; https://doi.org/10.3390/coatings6010009 - 18 Feb 2016

Cited by 2 | Viewed by 6724

Abstract

Bioengineering of dermal and epidermal cells on surface modified substrates is an active area of research. The cytotoxicity, maintenance of cell phenotype and long-term functionality of human dermal fibroblast (HDF) cells on conducting indium tin oxide (ITO) and semi-conducting, silicon (Si) and gallium arsenide (GaAs), surfaces modified with self-assembled monolayers (SAMs) containing amino (–NH₂) and methyl (–CH₃) end groups have been investigated. Contact angle measurements and infrared spectroscopic studies show that the monolayers are conformal and preserve their functional end groups. Morphological analyses indicate that HDFs grow well on all substrates except GaAs, exhibiting their normal spindle-shaped morphology and exhibit no visible signs of stress or cytoplasmic vacuolation. Cell viability analyses indicate little cell death after one week in culture on all substrates except GaAs, where cells died within 6 h. Cells on all surfaces proliferate except on GaAs and GaAs-ODT. Cell growth is observed to be greater on SAM modified ITO and Si-substrates. Preservation of cellular phenotype assessed through type I collagen immunostaining and positive staining of HDF cells were observed on all modified surfaces except that on GaAs. These results suggest that conducting and semi-conducting SAM-modified surfaces support HDF growth and functionality and represent a promising area of bioengineering research. Full article

(This article belongs to the Special Issue Self-assembled Monolayers and Multilayers (SAMs/SAMTs) for Medicine and Dentistry)

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Graphical abstract

1825 KiB

Open AccessArticle

Synthesis of a pH- and Thermo- Responsive Binary Copolymer Poly(N-vinylimidazole-co-N-vinylcaprolactam) Grafted onto Silicone Films

by Ángela Obando-Mora, Claudia A. Acevedo-Gutiérrez, Jesica G Pérez-Cinencio, Francis S. Sánchez-Garzón and Emilio Bucio

Coatings 2015, 5(4), 758-770; https://doi.org/10.3390/coatings5040758 - 30 Oct 2015

Cited by 5 | Viewed by 5958

Abstract

This work focuses on the effects of gamma-ray irradiation conditions on the stimuli-responsiveness of silicone rubber (SR) substrates grafted with N-vinylcaprolactam (NVCL) and N-vinylimidazole (NVIM), modified by the simultaneously polymerization and grafting method, which is expected to result in valuable new applications in the near future. The modification of silicone rubber was carried out via γ-ray radiation in order to graft a binary copolymer, poly(N-vinylimidazole-co-N-vinylcaprolactam), by the pre-irradiation method, to obtain pH- and thermo-responsive materials. The grafting yield was found to be directly proportional to the dose and monomers concentration. The biomaterials were characterized by using Fourier-transform infrared attenuated total reflection (FTIR-ATR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and swelling; and their stimuli behavior was evaluated by lower critical solution temperature (LCST) and pH critical studies. Full article

(This article belongs to the Special Issue Self-assembled Monolayers and Multilayers (SAMs/SAMTs) for Medicine and Dentistry)

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Review

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281 KiB

Open AccessReview

Surface Treatments and Functional Coatings for Biocompatibility Improvement and Bacterial Adhesion Reduction in Dental Implantology

by Pietro Mandracci, Federico Mussano, Paola Rivolo and Stefano Carossa

Coatings 2016, 6(1), 7; https://doi.org/10.3390/coatings6010007 - 27 Jan 2016

Cited by 124 | Viewed by 12307

Abstract

Surface modification of dental implants is a key process in the production of these medical devices, and especially titanium implants used in the dental practice are commonly subjected to surface modification processes before their clinical use. A wide range of treatments, such as sand blasting, acid etching, plasma etching, plasma spray deposition, sputtering deposition and cathodic arc deposition, have been studied over the years in order to improve the performance of dental implants. Improving or accelerating the osseointegration process is usually the main goal of these surface processes, but the improvement of biocompatibility and the prevention of bacterial adhesion are also of considerable importance. In this review, we report on the research of the recent years in the field of surface treatments and coatings deposition for the improvement of dental implants performance, with a main focus on the osseointegration acceleration, the reduction of bacterial adhesion and the improvement of biocompatibility. Full article

(This article belongs to the Special Issue Self-assembled Monolayers and Multilayers (SAMs/SAMTs) for Medicine and Dentistry)

726 KiB

Open AccessReview

The Porter-Whitesides Discrepancy: Revisiting Odd-Even Effects in Wetting Properties of n-Alkanethiolate SAMs

by Zhengjia Wang, Jiahao Chen, Stephanie Oyola-Reynoso and Martin Thuo

Coatings 2015, 5(4), 1034-1055; https://doi.org/10.3390/coatings5041034 - 21 Dec 2015

Cited by 28 | Viewed by 8499

Abstract

This review discusses the Porter-Whitesides discrepancy in wetting properties of n-alkanethiolate self-assembled monolayers (SAMs). About 25 years ago, Whitesides and coworker failed to observe any odd-even effect in wetting, however, Porter and his coworker did, albeit in select cases. Most previous studies agreed with Whitesides’ results, suggesting the absence of the odd-even effect in hydrophobicity of n-alkanethiolate SAMs. Recent reports have, however, found the odd-even effect in hydrophobicity of n-alkanethiolate SAMs on smooth substrates, indicating that hydrophobicity, and analogous interfacial properties, of n-alkanethiolate SAMs significantly depends on the properties of substrate. Unfortunately, the Whitesides and Porter papers do not report on the quality of the surfaces used. Based on recent work, we inferred that the original discrepancy between Whitesides and Porter can be attributed to the quality of the surface. Odd-even effect of SAMs in charge transport, capacitance, friction, and SAM structure are also discussed in this review to inform the general discussion. The discrepancy between Porter's group and Whitesides’ group could be due to surface roughness, morphology, oxidation, and adventitious contaminants. Full article

(This article belongs to the Special Issue Self-assembled Monolayers and Multilayers (SAMs/SAMTs) for Medicine and Dentistry)

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3592 KiB

Open AccessReview

Revisiting the Challenges in Fabricating Uniform Coatings with Polyfunctional Molecules on High Surface Energy Materials

by Stephanie Oyola-Reynoso, Zhengjia Wang, Jiahao Chen, Simge Çınar, Boyce Chang and Martin Thuo

Coatings 2015, 5(4), 1002-1018; https://doi.org/10.3390/coatings5041002 - 18 Dec 2015

Cited by 21 | Viewed by 10805

Abstract

Modifying the chemistry of a surface has been widely used to influence interfacial properties of a material or nature of interaction between two materials. This article provides an overview on the role of polyfunctional molecules, specifically silanes, in surface modification of polar surfaces (bearing soft nucleophiles). An emphasis on the mechanism of the reaction in the presence of adsorbed water, where the modifying reagents are hydrolysable, is discussed. To highlight the complexity of the reaction, modification of paper with trichlorosilanes is highlighted. Preparation of hydrophobic cellulosic paper, and structure–property relations under different treatment conditions is used to highlight that a monolayer is not always formed during the surface modification. Gel-formation via step-growth polymerization suggests that at the right monomer:adsorbed water ratio, a monolayer will not form but rather self-assembly driven particle formation will occur leading to a textured surface. The review highlights recent work indicating that the focus on monolayer formation, is at the very least, not always the case but gel formation, with concomitant self-assembly, might be the culprit in understanding challenges associated with the use of polyfunctional molecules in surface modification. Full article

(This article belongs to the Special Issue Self-assembled Monolayers and Multilayers (SAMs/SAMTs) for Medicine and Dentistry)

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