Advancing Coatings with Biotechnology II

A special issue of Coatings (ISSN 2079-6412).

Deadline for manuscript submissions: closed (31 December 2019) | Viewed by 4908

Special Issue Editor


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Guest Editor
1 Department of Chemical and Biomolecular Engineering, North Carolina State University, Campus Box 7905, Raleigh, NC 27695-7905, USA
2 Golden LEAF Biomanufacturing Training & Education Center, North Carolina State University, Campus Box 7928, Raleigh, NC 27695-7928, USA
Interests: Bioprocess Intensification and Miniaturization (BIM); bioreactive materials; biocatalytic coatings; biopreservation; nano-structured biocatalytic coatings and microbial inks; microbial biocatalyst engineering; biocoating reactor engineering
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Special Issue Information

Dear Colleagues,

Biotechnology has revolutionized many industries. It will dramatically impact the coating industry, by creating biocoatings with functionalities far beyond today's polymer coatings. A Special Issue of Coatings, combining biotechnology and coatings, has never before been published. This Special Issue will highlight advances in colloid and polymer materials, enzyme and microbial biotechnology that will dramatically transform the functionality of waterborne coatings using the selectivity and reactivity of biology. Biocoatings have been demonstrated in laboratory studies that preserve and stabilize the reactivity of enzymes, biomolecules (pigments, nucleic acids, proteins) or reactive microbes (bacteria, yeast, fungi, archea, algae) for hundreds to thousands of hours. Biocoatings can react to chemicals in the environment and degrade toxins; others are photoreactive producing or consuming gasses using solar energy. Some can be used as biocatalysts for chiral chemical transformations in aqueous or multi-phase systems, while others sense their environment (color change, luminesce, fluoresce) or self-tune to incident light intensity. There is a very significant gap between these academic demonstrations and the information needed for development of commercial biocoatings. Methods are needed for waterborne biocoating formulation, drying/curing without inactivation, wet adhesion, and optimization of nanoporosity. Modeling of the porosity, stability and reactivity of single or multi-component biocoatings is lacking. Close collaboration is needed between academic and industrial developers in the next 5 to 10 years to establish standards for measuring coating safety and stability for biocoatings to become commercial products proven in the market. This issue will highlight both the advances and the many challenges for commercial development of coatings utilizing biotechnology. Please contact me if you wish to discuss your contribution to this Special Issue on "Advancing Coatings with Biotechnology 2018".

Prof. Dr. Michael C. Flickinger
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Coatings is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • reactive enzyme coatings

  • biocatalytic coatings

  • photoreactive biocoatings

  • biocatalytic plastics

  • waterborne biocoatings

  • smart coatings using biotechnology

  • bioreactive polymer coatings

Published Papers (1 paper)

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Research

17 pages, 2799 KiB  
Article
Development of a Novel Polymer-Based mRNA Coating for Surgical Suture to Enhance Wound Healing
by Antonia Link, Hanna Haag, Tatjana Michel, Markus Denzinger, Hans Peter Wendel, Christian Schlensak and Stefanie Krajewski
Coatings 2019, 9(6), 374; https://doi.org/10.3390/coatings9060374 - 08 Jun 2019
Cited by 9 | Viewed by 4611
Abstract
A therapeutic strategy to improve wound healing has become an increasingly important medical task due to the rising incidence of adiposity and type II diabetes as well as the proceeding population aging. In order to cope with the resulting burdens, new strategies to [...] Read more.
A therapeutic strategy to improve wound healing has become an increasingly important medical task due to the rising incidence of adiposity and type II diabetes as well as the proceeding population aging. In order to cope with the resulting burdens, new strategies to achieve rapid and complete wound healing must now be developed. Accordingly, the development of a bioactive wound dressing in the form of a messengerRNA (mRNA)-bearing poly(lactide-co-glycolide acid) (PLGA) coating on surgical suture is being pushed further with this study. Furthermore, the evaluation of the polymer-based transfection reagent Viromer RED has shown that it can be used for the transfection of eukaryotic cells: The mRNA gets properly complexed and translated into a functional protein. In addition, the mRNA-PLGA coating triggered the expression of the keratinocyte growth factor (KGF) in HaCat cells although KGF is not expressed under physiological conditions. Moreover, transfection via surgical sutures coated with mRNA does not affect the cell viability and a proinflammatory reaction in the transfected cells is not induced. These properties make the mRNA-PLGA coating very attractive for the in vivo application. For the future, this could mean that through the use of mRNA-coated sutures in surgical wound closure, cells in the wound area can be transfected directly, thus accelerating and improving wound healing. Full article
(This article belongs to the Special Issue Advancing Coatings with Biotechnology II)
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