Crystallisation Control

A special issue of Crystals (ISSN 2073-4352).

Deadline for manuscript submissions: closed (15 December 2013)

Special Issue Editor

Department of Chemistry, University Science Laboratories, Durham University, Durham, DH1 3LE, UK
Interests: crystal growth; nucleation; crystallization in confined volumes; polymorphic control

Special Issue Information

Dear Colleagues,

Crystallisation is a vital process during the production of solid materials in many industrial and biological applications. Controlling the size, shape and polymorph of the crystals can be crucial in determining the properties of the materials that result. Crystallisation used to be considered rather a black art – scratch the glass sides of your reaction vessel and your organic crystals might ‘magically’ appear. Nowadays, however, scientists are often able to manipulate crystallisation processes with increasing reliability and sophistication to achieve their desired outcome. The advances in controlling crystallisation reflect our increasing understanding of the fundamental nucleation and crystal growth processes involved, though there are still gaps in our understanding that limit a full predictive capability. This special issue focuses on advances in any aspect of controlling crystallisation on any class of material, with the aim of highlighting the diversity of methods that can be used.

Dr. Sharon Jane Cooper
Guest Editor

Manuscript Submission Information

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Keywords

  • nucleation
  • crystal growth
  • polymorphism
  • cocrystals
  • crystallisation in confined volumes
  • crystallisation using ultrasound
  • laser-induced crystallisation
  • continuous crystallisation

Published Papers (1 paper)

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Research

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Article
From Evaporative to Cooling Crystallisation: An Initial Co-Crystallisation Study of Cytosine and Its Fluorinated Derivative with 4-chloro-3,5-dinitrobenzoic Acid
by Kate Wittering, Josh King, Lynne H. Thomas and Chick C. Wilson
Crystals 2014, 4(2), 123-140; https://doi.org/10.3390/cryst4020123 - 11 Jun 2014
Cited by 12 | Viewed by 6149
Abstract
Two new multi-component molecular complexes of cytosine and 5-fluorocytosine with 4-chloro-3,5-dinitrobenzoic acid are presented. Materials synthesis was achieved initially by evaporative crystallisation and the crystal structures determined. The process was then successfully transferred into a controlled small scale cooling crystallisation environment, with bulk [...] Read more.
Two new multi-component molecular complexes of cytosine and 5-fluorocytosine with 4-chloro-3,5-dinitrobenzoic acid are presented. Materials synthesis was achieved initially by evaporative crystallisation and the crystal structures determined. The process was then successfully transferred into a controlled small scale cooling crystallisation environment, with bulk samples shown to be representative of the multi-component product phase, by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) methods. Turbidity measurements are shown to be a valuable process analytical technology probe for characterising the initial stages of molecular complex formation in solution. The significance of these findings for scale-up of crystallisation of multi-component molecular materials and for future transfer into continuous cooling crystallisation is discussed. Full article
(This article belongs to the Special Issue Crystallisation Control)
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