Single Cell Epigenomics

Dear Colleagues,

Key aspects of biology frequently occur in small numbers of specialized cells, where the local action of transcription factors, chromatin remodelers, and chromatin modifiers govern downstream biological events. In the past, assessment of the localization of chromatin accessibility and modification, and the proteins mediating these events, was limited to the analysis of thousands to millions of cells. Outputs from such experiments often represent averages across heterogeneous cell populations and fail to capture cell type specific information instructing key biological events in development, differentiation, response to stimuli, and disease. Recent advances in instrumentation, experimental protocols, and data analysis are providing detailed views of the epigenomes of single cells or very small numbers of cells, providing new mechanistic insights into biological processes and into variability of responses at the cellular level.

This Special Issue is focused on single cell and ultra-low input approaches to epigenetics. We will consider reviews, research or method manuscripts of exceptional interest on the following topics:

• Genome-wide analysis of histone modification(s) or chromatin accessibility in single cells or small numbers of cells
• Alternative methods to conventional chromatin immunoprecipitation applicable to single cells or small numbers of cells
• Genome-wide analysis of DNA methylation in single cells or small numbers of cells
• Technical advances in experimental platform and instrumentation that empower single cell epigenetic data collection
• Advances in single cell epigenetic data analysis, including methods for inferring cell state trajectories, integrating multiple layers of epigenomic data, and testing for differences in epigenetic profiles between states or conditions.

Dr. Paul A. Wade
Dr. Justin A. Colacino
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Epigenomes is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.