Population Genetics and Genomics of Opportunistic and Drug-Resistant Bacterial Pathogens: Dealing with Complexity
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Microbial Genetics and Genomics".
Deadline for manuscript submissions: closed (30 September 2018)
Special Issue Information
Dear Colleagues,
The bacterial resistance to antimicrobial agents is presently an emerging global threat with a predicted health disaster on the 2050 horizon. Multi-drug resistance mainly concerns opportunistic bacteria, such as healthcare-associated pathogens and environmental pathogens, of which dynamics are influenced by global changes. These bacteria display versatile behaviors and adaptive ability, mainly based on a wide metabolic repertory and their great resistance to physicochemical agents, these traits resulting from complexity at various biological levels: Population genetics, mode of evolution, structure and content of the genome, organization in species complex rather than in true species, association of pathoadaptative traits rather than specific discrete virulence factors, etc. This complexity precludes the use of model organisms as the standard of a bacterial species, and makes population approaches obligatory. The development of new generation sequencing allows the study of microbial genetics and genomics at the population level, with major advances in phylotaxonomy, pathogenesis, epidemiology, infection control, and, more generally, in the understanding of the infectious success of opportunistic, healthcare-associated and drug-resistant pathogens.
This Special Issue is open to researchers willing to contribute significant original research, relevant observations, new concept or reviews in population genetics and the genomics of bacteria involved in opportunistic infections.
Sincerely,
Manuscript Submission Information
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Keywords
- Opportunistic human pathogens
- bacterial population studies
- bacterial genomics
- pathogenomics
- resistance to antimicrobial agents
- healthcare-associated infection
- environmental pathogens
