Special Issue "Protein-DNA Interactions"
Deadline for manuscript submissions: 31 May 2017
The binding of proteins to DNA is critical for maintaining and expressing genetic information. Protein-DNA interactions are involved in condensing chromosomes to fit into cells, regulating the expression of genetic information, duplicating the genome to pass copies to daughter cells, and preserving the structure and integrity of genomic DNA. Our understanding of protein-DNA interactions required for these critical functions has advanced on many levels. Structural approaches have elucidated mechanisms by which proteins physically interact with DNA to perform their functions. Biochemical studies have defined dynamic and transient protein-DNA interactions essential for enzyme transactions on DNA. Recently, exciting progress has been made in two areas: single molecule and in vivo studies of protein-DNA interactions. Single molecule approaches reveal the complex dynamics of molecular interactions between single protein molecules and DNA that are hidden by the ensemble averaging inherent in bulk methods. Observation of the behavior of individual molecules allows us to answer questions that are impossible to address by examining a large population of molecules where the dynamics are unsynchronized, and thus “blur” the picture that we get. Exciting progress has also been made in investigating protein-DNA interactions inside cells in the crowded and complex molecular environment where they naturally function. Researchers have been able to query unique loci to identify protein-DNA interactions that are required for a specific cellular process, and recent advances in DNA sequencing have permitted the development of approaches to map protein-DNA interactions across the genome and in a cell-type specific manner. These studies revealed that DNA shape and DNA motif environment contribute to efficient protein-DNA interactions. Articles in this special issue should provide insight into mechanisms of protein-DNA interactions, and papers using single-molecule approaches or investigating interactions in vivo would be of special interest.
Prof. Dr. Linda Bloom
Prof. Dr. Jörg Bungert
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed Open Access monthly journal published by MDPI.
• chromatin structure
• DNA replication
• DNA repair
• DNA recombination