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Special Issue "R-loop Biology in Eukaryotes"

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics".

Deadline for manuscript submissions: 31 March 2017

Special Issue Editor

Guest Editor
Prof. Dr. Frédéric Chédin

Department of Molecular and Cellular Biology, University of California Davis, Davis, CA 95616, USA
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Special Issue Information

Dear Colleagues,

Over the past decade, our understanding of the biology of R-loop structures in Eukaryotes has made tremendous progress. We now know that R-loop formation is a prevalent and dynamic component of the eukaryotic chromatin that is subject to careful regulation in time and space. Accumulating evidence has convincingly linked R-loop structures to numerous nuclear processes including transcription, DNA replication, DNA repair, DNA recombination, and chromatin patterning. Not surprisingly, perturbations in R-loop metabolism cause various forms of nuclear stress and have been linked to multiple human diseases. In recognition of this progress, we would like to commission what is likely to be the first book focused on this topic. The goal of this special issue of Genes is to provide both newcomers and experts a comprehensive and up to date overview of the field, its progress, its challenges, and its future. Proposed topics for the series will cover both model organisms and mammalian systems including humans. A non-exhaustive list of topics to be covered will include global R-loop mapping, analysis of R-loop formation and resolution pathways, links between perturbations in R-loop homeostasis and genomic instabilility, possible physiological roles of R-loop structures in chromatin patterning, transcriptional control, and recombination initiation as well as roles for R-loop dysfunction in human diseases.

We welcome your participation in this exciting endeavor and hope you will contribute your expertise in the form of a review or original article.

Prof. Dr. Frédéric Chédin
Guest Editor

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs).

Keywords

  • R-loop
  • transcription
  • chromatin
  • genomic instability
  • DNA breaks
  • disease

Published Papers (1 paper)

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Review

Open AccessReview Replication Fork Protection Factors Controlling R-Loop Bypass and Suppression
Genes 2017, 8(1), 33; doi:10.3390/genes8010033
Received: 28 October 2016 / Revised: 2 January 2017 / Accepted: 9 January 2017 / Published: 14 January 2017
PDF Full-text (557 KB) | HTML Full-text | XML Full-text
Abstract
Replication–transcription conflicts have been a well-studied source of genome instability for many years and have frequently been linked to defects in RNA processing. However, recent characterization of replication fork-associated proteins has revealed that defects in fork protection can directly or indirectly stabilize R-loop
[...] Read more.
Replication–transcription conflicts have been a well-studied source of genome instability for many years and have frequently been linked to defects in RNA processing. However, recent characterization of replication fork-associated proteins has revealed that defects in fork protection can directly or indirectly stabilize R-loop structures in the genome and promote transcription–replication conflicts that lead to genome instability. Defects in essential DNA replication-associated activities like topoisomerase, or the minichromosome maintenance (MCM) helicase complex, as well as fork-associated protection factors like the Fanconi anemia pathway, both appear to mitigate transcription–replication conflicts. Here, we will highlight recent advances that support the concept that normal and robust replisome function itself is a key component of mitigating R-loop coupled genome instability. Full article
(This article belongs to the Special Issue R-loop Biology in Eukaryotes)
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