Special Issue "R-loop Biology in Eukaryotes"
Deadline for manuscript submissions: 31 March 2017
Over the past decade, our understanding of the biology of R-loop structures in Eukaryotes has made tremendous progress. We now know that R-loop formation is a prevalent and dynamic component of the eukaryotic chromatin that is subject to careful regulation in time and space. Accumulating evidence has convincingly linked R-loop structures to numerous nuclear processes including transcription, DNA replication, DNA repair, DNA recombination, and chromatin patterning. Not surprisingly, perturbations in R-loop metabolism cause various forms of nuclear stress and have been linked to multiple human diseases. In recognition of this progress, we would like to commission what is likely to be the first book focused on this topic. The goal of this special issue of Genes is to provide both newcomers and experts a comprehensive and up to date overview of the field, its progress, its challenges, and its future. Proposed topics for the series will cover both model organisms and mammalian systems including humans. A non-exhaustive list of topics to be covered will include global R-loop mapping, analysis of R-loop formation and resolution pathways, links between perturbations in R-loop homeostasis and genomic instabilility, possible physiological roles of R-loop structures in chromatin patterning, transcriptional control, and recombination initiation as well as roles for R-loop dysfunction in human diseases.
We welcome your participation in this exciting endeavor and hope you will contribute your expertise in the form of a review or original article.
Prof. Dr. Frédéric Chédin
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed Open Access monthly journal published by MDPI.
- genomic instability
- DNA breaks