Special Issue "Wnt Signaling in Stem Cells"

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics".

Deadline for manuscript submissions: 30 November 2017

Special Issue Editors

Guest Editor
Prof. Dr. Ethan Lee

Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37240, USA
Website | E-Mail
Interests: Wnt signaling; Xenopus laevis; biochemistry; ubiquitination; chemical biology; systems biology
Guest Editor
Prof. Dr. Yashi Ahmed

Department of Molecular and Systems Biology and the Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH 03755, USA
Website | E-Mail
Interests: Wingless; Drosophila genetics; APC, ADP-ribosylation; intestinal stem cells Introduction
Guest Editor
Prof. Dr. Robert J. Coffey

Department of Cell and Developmental Biology and Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Website | E-Mail
Interests: EGFR; Epithelial Polarity; Vesicle Trafficking; Wnt signaling; Naked2; GI Cancer

Special Issue Information

Dear Colleagues,

We write to invite you to contribute to a Special Issue in Genes that will be focused on Wnt signalling in stem cells. Originally identified as an evolutionarily conserved key determinant of embryonic patterning and an oncogenic pathway, Wnt signaling has been shown to play a major role in the maintenance, renewal, and differentiation of a number of stem cell lineages in the adult multicellular organism (including gastrointestinal, hematopoietic, neural, mammary, epidermal, follicular, testicular, and ovarian lineages). Thus, modulating this pathway has enormous potential in regenerative medicine and in the treatment of major human cancers. Major questions that are currently being investigated include the role of Wnt signaling in regulating stem cell self-renewal, proliferation, and differentiation as well as the characterization of cells in the niche that produce and receive the Wnt signal. In addition, the detailed mechanisms by which the Wnt pathway is controlled and maintained in the stem cell niche remain ill defined.

This Special Issue will highlight reviews, new methods, and original articles that advance our understanding of the Wnt pathway and its role in stem cell biology. We welcome contributions in the areas of Wnt/b-catenin as well as noncanonical Wnt signaling, as both have been implicated in stem cell regulation. Topics of interest include, but are not limited to, the role of Wnt signaling in maintenance, proliferation, and differentiation of stem cells of various organ lineages; the role of Wnt signaling in embryonic stem cells and cancer stem cells; and the role of Wnt signaling in controlling and regulating stem cell niches. We also welcome studies that highlight new technologies, new modes of regulation, and/or novel components of the Wnt signaling pathway that reveal underlying biochemical mechanisms that may ultimately control stem cell behavior. Finally, we welcome studies that make use of traditional as well as non-traditional model organisms that may provide insight into the evolutionarily conserved role of Wnt signaling in stem cell function across phyla. We look forward to your contributions.

Prof. Dr. Ethan Lee
Prof. Dr. Yashi Ahmed
Prof. Dr. Robert J. Coffey
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Wnt signaling
  • stem cells
  • development
  • regenerative medicine
  • cancer
  • model organisms

Published Papers

This special issue is now open for submission.
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