Special Issue "Environmental Neurotoxicology"
A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601).
Deadline for manuscript submissions: 31 March 2017
Prof. Dr. Peter S. Spencer
Department of Neurology, School of Medicine, and Oregon Institute for Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239, USA
Phone: 503 209-0986
Interests: neurotoxinology (plant, fungal); neurotoxicology; systems biology; human disease Contribution: Special Issue: Neurotoxins: Health Threats and Biological Tools
Definitive evidence of cause and effect in human environmental neurotoxic disease is rare, in part because chemical exposures are diverse, focus is usually placed on a narrow subset, disease incubation may be prolonged, and experimental studies for assessing individual substances are time-consuming and expensive. Furthermore, the results obtained from laboratory models may be challenging to extrapolate to humans. These limitations notwithstanding, this research provides the opportunity to discover which and how natural and synthetic chemical substances cause neurological illness, both in individuals and in populations. The discovery of causation can lead to primary disease prevention. When this logic is applied to human sporadic neurodegenerative disorders, where the current research focus is placed on treatments for delaying clinical expression and advance, the human health and financial impacts of primary disease prevention become apparent. While this is an important component of environmental neurotoxicology, researchers are more often more focused on assessing the health risks from exposure to agents that are known or perceived to have neurotoxic potential, with uncertain extrapolations made from laboratory animal and human health. Finally, as much as neurotoxicology is concerned with the adverse affects of chemical agents on the nervous system, once the chemical culprits are convincingly identified and the mechanisms of attack understood, the same chemicals become valuable tools for the basic neuroscientist to probe nervous system function and dysfunction.
The present collection of invited papers reflects the above biases, approaches, and contributions. Importantly, the net is spread widely, in that the term “environment” is interpreted to include the totality of exogenous chemicals to which humans are exposed, whether in the air, food or water. Substances used in medicine are omitted, even though many have the potential to cause nervous system damage or dysfunction. These include drugs that are used in treating cancer and epilepsy, in anesthesia and psychiatry, and in the treatment of infections and parasites. Other deliberate omissions from this volume are chemicals used to induce euphoria, including alcohol and certain drugs, which also have significant neurotoxic potential. The public health impact from the neurotoxic effects of medicines and drugs is substantial, but beyond the focus of this volume.
Prof. Peter S. Spencer
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed Open Access monthly journal published by MDPI.
- Neurologic disease
- Neurodegenerative disorders