Special Issue "Innovations in Exposure Assessment for the Sound Management of Chemicals"
A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601).
Deadline for manuscript submissions: closed (31 May 2014)
Dr. Peter P. Egeghy (Website)
National Exposure Research Laboratory, U.S. Environmental Protection Agency, Mail Drop E205-04, Research Triangle Park, NC 27711, USA
Interests: rapid risk assessment; chemical screening and prioritization; household product chemical exposure; accelerated exposure assessment; exposure database development; exposure variability; biological markers
Dr. Michael-Rock Goldsmith (Website)
National Exposure Research Laboratory, U.S. Environmental Protection Agency, Mail Drop E205-01, Research Triangle Park, NC 27711, USA
Fax: 1-919- 685-3120
Interests: In silico / computational pharmacokinetic and dosimetric modeling; application of chemical genomics to in vitro to in vivo extrapolation; implications of stereochemistry on quantitative risk assessment; personal household chemical exposure informatics with actigraphy integration; low-cost remote sensing technologies; and mapping, visualization, and modeling, using unconventional technologies.
The manufacture and use of chemicals have increased significantly over the past half century. Synthetic chemicals are now integrated into nearly all industrial processes and consumer products, with approximately 30,000 substances believed to be in wide commercial use. Information regarding risks posed to human health and the environment from the growing dependence on chemicals is inadequate, but momentum is building worldwide for better management of these risks. Human biomonitoring surveys have demonstrated widespread human exposure to large numbers of industrial chemicals, therefore changing public perceptions of environmental contamination. Moreover, there is increasing recognition that the most important pathways of exposure do not necessarily involve ambient air or drinking water, but instead may be much more direct; said pathways may often originate from consumer products and other residential sources. The scientific community is becoming aware that traditional sampling strategies and measurement techniques for characterizing exposure are inadequate for addressing hundreds, much less thousands, of chemicals. Our enhanced understanding of the inherent spatial and temporal variability of chemical exposure, of the importance of critical windows of susceptibility, and of the role of human activities in precipitating exposure, is driving fundamental changes in exposure science.
The practice of exposure assessment must change substantially to achieve the recommendations of the 2007 National Research Council (NRC) of the National Academy of Sciences report on Toxicity Testing in the 21st Century and the 2012 NRC report on Exposure Science in the 21st Century. Technological advances to support more efficient and effective means of screening chemicals for potential risk must include new tiered modeling approaches to predict exposure, as well as the development of broad, high-throughput analytical methods and novel biological and chemical sensors. The exposure community is beginning to embrace citizen science and social networking mechanisms to engage the public and benefit from their creativity, innovation, and enthusiasm. Tools and models from several social sciences (e.g., consumer marketing research, applied behavior analysis, social anthropology, etc.) are being integrated into exposure assessment to better understand the complex social behaviors that determine human exposures and to identify key drivers of chemical exposure potential. Continuing advances in technology and information architecture are providing the tools needed to perform risk assessment of chemicals in a more rapid, efficient, and cost-effective way.
Integration of hazard, exposure, effects, and behavioral information is advancing the sound management of chemicals, while transcending the traditional disciplinary boundaries of the risk assessment paradigm. This special issue, “Innovations in Exposure Assessment for the Sound Management of Chemicals,” invites contributions that will demonstrate innovative analytical or computational approaches to exposure assessment for chemical risk management.
Dr. Peter P. Egeghy
Dr. Michael-Rock Goldsmith
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- exposure-based chemical prioritization
- high throughput exposure assessment
- tiered risk assessment
- rapid risk assessment
- chemicals management
- exposure metrics
- comprehensive environmental monitoring
- environmental chemicals
- contaminants of emerging concern
- environmental metabolomics
- chemical screening
- rapid prioritization
- consumer products
- citizen science
- exposure informatics
- big data
- environmental anthropology
- optical sensor microarrays
- carbon nanotube transistors
- geographic information system (GIS)
- aggregate exposure
- pollution monitoring