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Social Stressors and Susceptibility to Chemical Exposures

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Global Health".

Deadline for manuscript submissions: closed (31 July 2019) | Viewed by 6171

Special Issue Editor


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Guest Editor
Department of Environmental and Occupational Health, Dornsife School of Public Health, Drexel University, Philadelphia, PA 19104, USA
Interests: social susceptibility to environmental pollution; air pollution; spatial analysis; GIS; social epidemiology

Special Issue Information

Dear Colleagues,

Substantial evidence indicates greater susceptibility to chemical exposures, including air pollution, in communities of lower socioeconomic position (SEP). The reasons underlying this susceptibility, however, remain unidentified, and may include factors as varied as material deprivation, resource access, health behaviors, aspects of the social environment, and/ or chronic stress associated with financial strain, safety concerns, housing, or many other stressors which may be more prevalent in lower-SEP communities. Growing evidence suggests that chronic psychosocial stress may drive a substantial portion of this SEP-related susceptibility, and may operate via immune, endocrine, metabolic, or other biologic processes.

This Special Issue seeks qualitative and quantitative papers on the combined effects of psychosocial stress and physical environmental exposures on health, throughout the life cycle. Specific emphasis will be placed on papers advancing methods for investigating combined effects, including exposure assessment for chemical and non-chemical exposures at the individual or aggregate (community, workplace, etc.) level, and statistical methods to quantify joint contributions. Empirical epidemiologic and mechanistic studies will be considered. High-quality qualitative and/ or systematic reviews will be also considered.

Prof. Jane E. Clougherty
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic stress
  • psychosocial stress
  • socioeconomic position (SEP)
  • urban health
  • susceptibility
  • pollution
  • chemical/ non-chemical exposures
  • mixtures
  • synergistc effects
  • interactions

Published Papers (2 papers)

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Research

19 pages, 1572 KiB  
Article
Putting Co-Exposures on Equal Footing: An Ecological Analysis of Same-Scale Measures of Air Pollution and Social Factors on Cardiovascular Disease in New York City
by Jamie L. Humphrey, Colleen E. Reid, Ellen J. Kinnee, Laura D. Kubzansky, Lucy F. Robinson and Jane E. Clougherty
Int. J. Environ. Res. Public Health 2019, 16(23), 4621; https://doi.org/10.3390/ijerph16234621 - 21 Nov 2019
Cited by 8 | Viewed by 2568
Abstract
Epidemiologic evidence consistently links urban air pollution exposures to health, even after adjustment for potential spatial confounding by socioeconomic position (SEP), given concerns that air pollution sources may be clustered in and around lower-SEP communities. SEP, however, is often measured with less spatial [...] Read more.
Epidemiologic evidence consistently links urban air pollution exposures to health, even after adjustment for potential spatial confounding by socioeconomic position (SEP), given concerns that air pollution sources may be clustered in and around lower-SEP communities. SEP, however, is often measured with less spatial and temporal resolution than are air pollution exposures (i.e., census-tract socio-demographics vs. fine-scale spatio-temporal air pollution models). Although many questions remain regarding the most appropriate, meaningful scales for the measurement and evaluation of each type of exposure, we aimed to compare associations for multiple air pollutants and social factors against cardiovascular disease (CVD) event rates, with each exposure measured at equal spatial and temporal resolution. We found that, in multivariable census-tract-level models including both types of exposures, most pollutant–CVD associations were non-significant, while most social factors retained significance. Similarly, the magnitude of association was higher for an IQR-range difference in the social factors than in pollutant concentrations. We found that when offered equal spatial and temporal resolution, CVD was more strongly associated with social factors than with air pollutant exposures in census-tract-level analyses in New York City. Full article
(This article belongs to the Special Issue Social Stressors and Susceptibility to Chemical Exposures)
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16 pages, 683 KiB  
Article
The Cumulative Risk of Chemical and Nonchemical Exposures on Birth Outcomes in Healthy Women: The Fetal Growth Study
by Leah Zilversmit Pao, Emily W. Harville, Jeffrey K. Wickliffe, Arti Shankar and Pierre Buekens
Int. J. Environ. Res. Public Health 2019, 16(19), 3700; https://doi.org/10.3390/ijerph16193700 - 01 Oct 2019
Cited by 15 | Viewed by 3170
Abstract
Metals, stress, and sociodemographics are commonly studied separately for their effects on birth outcomes, yet often jointly contribute to adverse outcomes. This study analyzes two methods for measuring cumulative risk to understand how maternal chemical and nonchemical stressors may contribute to small for [...] Read more.
Metals, stress, and sociodemographics are commonly studied separately for their effects on birth outcomes, yet often jointly contribute to adverse outcomes. This study analyzes two methods for measuring cumulative risk to understand how maternal chemical and nonchemical stressors may contribute to small for gestational age (SGA). SGA was calculated using sex-specific fetal growth curves for infants of pregnant mothers (n = 2562) enrolled in the National Institute of Child Health and Human Development (NICHD) Fetal Growth Study. The exposures (maternal lead, mercury, cadmium, Cohen’s perceived stress, Edinburgh depression scores, race/ethnicity, income, and education) were grouped into three domains: metals, psychosocial stress, and sociodemographics. In Method 1 we created cumulative risk scores using tertiles. Method 2 employed weighted quantile sum (WQS) regression. For each method, logistic models were built with three exposure domains individually and race/ethnicity, adjusting for age, parity, pregnancy weight gain, and marital status. The adjusted effect of overall cumulative risk with three domains, was also modeled using each method. Sociodemographics was the only exposure associated with SGA in unadjusted models ((odds ratio) OR: 1.35, 95% (confidence interval) CI: 1.08, 1.68). The three cumulative variables in adjusted models were not significant individually, but the overall index was associated with SGA (OR: 1.17, 95% CI: 1.02, 1.35). In the WQS model, only the sociodemographics domain was significantly associated with SGA. Sociodemographics tended to be the strongest risk factor for SGA in both risk score and WQS models. Full article
(This article belongs to the Special Issue Social Stressors and Susceptibility to Chemical Exposures)
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