Special Issue "Dental Materials"
Deadline for manuscript submissions: closed (30 June 2011)
Prof. Dr. Jorge Perdigão (Website)
University of Minnesota, Department of Restorative Sciences, Division of Operative Dentistry, 515 SE Delaware St, 8-450 Moos Tower, Minneapolis, MN 55455, USA
Dental research has been transitioning gradually from the classical Restorative Dentistry to Regenerative Dentistry. Regeneration of a functional tooth is a promising strategy for replacing an irreversibly diseased tooth. Pulp-like tissue can now be regenerated in root canal space by stem cells and give rise to odontoblast-like cells producing dentin-like tissue. Three-dimensional porous scaffolds made of mineralized type I collagen mimic the composition of extracellular matrix ofbone and can therefore have the potential of being used as a biomimetic graft material. Additionally, the role of RNA interference (RNAi) and RNA activation (RNAa) may prove to be crucial to treat or prevent dental anomalies and periodontal disease.
The role of metalloproteinases (or MMP’s) inhibitors in preventing the degradation of dentinal collagen fibers has been recently highlighted in dentin adhesion. Other promising areas of research in dental adhesion are the application of colloidal platinum nanoparticles, and guided tissue mineralization to re-mineralize areas etched by phosphoric acid but not infiltrated by the adhesive.
Some of the dental materials recently introduced - low-shrinkage resin composites and Y-TZP-based fixed prostheses - have changed some of the classical concepts of clinical dentistry.
For the first time in 40 years, dentists are using a non-BisGMA resin composite. Shrinkage stresses are reduced with the new silorane-based resin composites. The relevance of using low- or no-shrinking composite materials is that internal stresses occur during the polymerization of all dental composites due to a volumetric contraction. These shrinkage stresses may cause interfacial failures between the restoration and the tooth structure.
Yttria-stabilized tetragonal zirconia (Y-TZP) and titanium implants have been increasingly used in Dentistry. Y-TZP is used as the infrastructure for crowns, bridges and implant abutments. Research in Clinical Orthopedics has shown that Y-TZP used in hip arthroplasties may undergo transformation under mechanical and/or hydrothermal stress, with degradation of mechanical and tribologic properties. It is not known if these alterations also occur in Y-TZP dental restorations.
Prof. Dr. Jorge Perdigão
- nanotechnology in Dentistry
- dental pulp & regeneration
- scaffold materials
- stem cells in dentistry
- dental tissue bioengineering
- RNA interference
- dentin ultrastructure & adhesion
- dentin MMP's & collagen
- non-shrinking composite materials
- biodegradation of Y-TZP
- optimization of dental implant surfaces