Drosophila Model and Human Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 August 2018) | Viewed by 117594
Special Issue Editor
Interests: drosophila model; development; cell cycle control; microtubule transport; mRNA localization; multifunctional proteins; human disease; cancer
Special Issue Information
Dear Colleagues,
Many molecular and cellular mechanisms that drive the physiological functions of cells or control the development of an animal are well conserved between vertebrates and insects. This conservation made the genetically and experimentally tractable Drosophila a valuable model to study human development and diseases. The high similarity of these processes is illustrated by the fact that close to two out of three human disease genes have Drosophila counterparts that are thought to be functional homologs.
The availability of extensive resources and sophisticated genetic tools allows researchers to efficiently generate Drosophila disease models for numerous disorders with the goal of identifying the etiology of these human diseases. The knowledge about the disease pathway often points to novel possible therapeutic targets and whole organism screening for compounds that interact with the pathway. Because Drosophila allows the researchers to adjust the genetic background, whole organism Drosophila disease models will play an important role in the future of personalized medicine. For this Special Issue, we welcome original research articles and reviews that provide novel insights into the outlined research areas.
Prof. Dr. Beat Suter
Guest Editor
Manuscript Submission Information
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Keywords
- Drosophila melanogaster
- human disease model
- neurodegeneration
- cancer model
- developmental defects
- defects in physiology
- experimental genetics model
- whole organism model
- disease etiology