Special Issue "Mechanism of Action and Applications of Cytokines in Immunotherapy"
Deadline for manuscript submissions: closed (30 June 2015)
Prof. Dr. Kamal D. Moudgil
Department of Microbiology and Immunology, University of Maryland School of Medicine, 685 W. Baltimore Street, HSF-1, Suite 380 Baltimore, MD 21201, USA
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Interests: autoimmunity; arthritis; immune regulation; cytokines; antigen processing and presentation; natural products; targeted therapy
Cytokines can be produced by a wide variety of cell types, including lymphocytes, myeloid cells, endothelial cells, and epithelial cells (under appropriate stimuli). Cytokines mediate diverse cellular, biochemical, and molecular responses in health, as well as during infection and other pathophysiological situations, including tumors and autoimmune diseases. Certain cytokines induce inflammation and tissue damage, whereas others attempt to suppress inflammation and facilitate tissue repair or recovery. Accordingly, cytokines have been broadly categorized as either pro-inflammatory or anti-inflammatory in nature. In regard to the cellular sources of such cytokines, for example, the T helper 17 (Th17) cells that produce IL-17 are involved in the pathogenesis of many autoimmune diseases, whereas the T regulatory (Treg) cells that produce IL-10 and TGF-β regulate pathogenic responses. Furthermore, different cytokines may reveal cooperative or antagonistic attributes in the course of immune dysregulation, cell death, and other pathological events. In the past decade or so, many new cytokines and effector/regulatory lymphocyte subsets have been unveiled. Also described are new subsets of macrophages and other myeloid cells. These advances have prompted an enthusiastic search for the mechanisms of action of newly discovered cytokines and their inter-relationships with previously well-known (older) cytokines. The emerging information, in turn, has stimulated the development of novel cytokine-based strategies for therapeutic purposes. For example, a spectrum of biologics is either in use or under development for the treatment of various autoimmune diseases. Similarly, strategies for the modulation of cellular/cytokine activity, so as to enhance anti-tumor immunity, are being developed. This Special Issue discusses the mechanisms of action and applications of cytokines for immunotherapeutic purposes.
Prof. Dr. Kamal D. Moudgil
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.
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