Special Issue "Molecular Research in Urology 2014"
Deadline for manuscript submissions: closed (15 June 2014)
Prof. Dr. Jack A. Schalken
Research Director Urology, Dept. of Urology, University Hospital Nijmegen, Box 9101, Nijmegen NL-6500 HB, The Netherlands
Website | E-Mail
Interests: molecular and cellbiology of oncological diseases; cadherine mediated interactions and signal transductions; molecular diagnostics; urogenital oncology; veterinary oncology
The unmet needs in prostate cancer diagnosis and therapy are diverse; there is an urgent need for biomarkers that can be used for the early diagnosis of patients with clinically significant prostate cancer. Significant steps forward have been made and are reviewed in this issue. Once metastasized, there is still no effective treatment, nor stand alone a curative therapy. However, an improved understanding of sustained androgen receptor signaling in CRPC has now led to more effective therapies. Apart from a better insight in the molecular aspects of prostate carcinogenesis and progression, we need to understand tumor cell biology. Identification of cancer initiating cells and therapies targeted to eradicate these population(s) are the way forward to combat this disease.
Prof. Dr. Jack A. Schalken
Dr. Nees Matthias
Manuscript Submission Information
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- biomarkers (diagnostic prognostic and predictive)
- androgen receptor targeted therapy
- novel targets for therapy
- cancer initiating cells