Special Issue "Advances in Molecular Neuropathology"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (15 December 2008)
Prof. Dr. Kurt A. Jellinger
Institute of Clinical Neurobiology, Alberichgasse 5/13, A1150 Wien, Austria
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Interests: alzheimer disease; classification of proteinopathies; dementia; dementia with Lewy bodies; immunohistochemistry; Lewy bodies; mild cognitve impairment; movement disorders; multiple system atrophy; neurodegeneration; neuropathology; Parkinson disease; pathogenesis of dementia and movement disorders; pathology and diagnosis of dementia and movement disorders; tau-pathology; vascular dementia; α-synuclein pathology
During the recent years, considerable progress has been achieved in molecular genetics, pathogenesis and pathology of many nervous system disorders, based on new and modern technologies and animal models.
In the field of tumors of the CSN, the new 2007 classification, based on modern molecular genetics, immunocytochemistry and proteomics, has provided deeper insights into the pathogenesis and molecular pathobiology of CNS malignancies and has listed several new entities to the existing grading system, thus broadening the diagnostic spectrum and prognostic factors.
Modern research in inflammatory disorders of the nervous system has been focused on different types of multiple sclerosis (MS), their molecular and immunopathology, as well as on new molecular genetic findings and animal models of MS and related disorders, such as neuromyelitis optica and immun-mediated neuropathies, neuro-AIDS (CNS-HIV), and the relations between neuroinflammation and neurodegeneration.
One of the fields of most intensive and successful research is neurodegeneration and dementias, where many new phenotypes have been detected and classified using modern molecular genetics and animal and cellular models. Although the etiology and pathogenesis of Alzheimer disease and many other neurodegenerative and dementing disorders are still far from being elucidated, recent studies have provided important and meaningful results about the role of protein misfolding in neurodegeneration, eg, in the relationship of β-amyloid and tau protein in the pathogenesis of brain aging and Alzheimer disease, the role of α-synuclein and tau in neurodegeneration. Modern research has detected new forms of neurodegenerative disorders, such as the TDP-43-pathies, but has also provided new insights into the pathogenesis and molecular pathology of well-known entities, such as CAG repeat disorders, motor neuron diseases, prion diseases, peroxisomal and mitochondrial disorders.
The present special issue will present various aspects of modern research in molecular neuropathology in order to provide new impacts for further research in this up-to-date field of neurosciences.
Prof. Dr. Kurt A. Jellinger
- molecular neuropathology
- molecular genetics
- pathogenesis of nervous system disorders
- classification of CNS tumors
- multiple sclerosis
- neurodegenerative diseases
- Alzheimer disease
- protein misfolding diseases
- prion diseases