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Inorganics
Special Issues
Metal Complexes for Imaging and Therapy
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Metal Complexes for Imaging and Therapy

A special issue of Inorganics (ISSN 2304-6740). This special issue belongs to the section "Bioinorganic Chemistry".

Deadline for manuscript submissions: closed (15 November 2017)

Special Issue Editors

Prof. Dr. António Paulo

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Guest Editor
C2TN- Centro de Ciências e Tecnologias Nucleares and DECN - Departamento de Engenharia e Ciências Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal
Interests: inorganic chemistry; medicinal chemistry; radiopharmaceutical chemistry; nuclear medicine; nanomedicine
Dr. João D. G. Correia

E-Mail Website
Guest Editor
Departamento de Engenharia e Ciências Nucleares and Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, CTN, Estrada Nacional 10 (Km 139,7), 2695-066 Bobadela LRS, Portugal
Interests: molecular imaging; nuclear chemistry; radiopharmaceutical chemistry; theranostics; metallodrugs; peptides; targeted radionuclide therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The design of novel metal-based compounds plays an important role in the development of innovative drugs for diagnostic or therapeutic applications. Such compounds present a set of intrinsic advantages related to their structural diversity and unique magnetic, radiochemical, and electrochemical properties. Indeed, metal complexes have emerged in the past few years as very versatile tools to develop new cytotoxic drugs for cancer therapy, radiopharmaceuticals for nuclear imaging or radionuclide therapy and contrast agents for magnetic resonance imaging, just to mention a few representative examples. The physicochemical properties of the complex itself are key to obtain the desired imaging/therapeutic effects, whereas its functionalization with specific biomolecules is of great importance to achieve target organ/tissue-preferential accumulation, taking advantage from the advances in bioconjugation strategies and chemical biology. This Special Issue of Inorganics will focus on the most relevant chemical aspects and biological features of important classes of metallodrugs, i.e.,:

  • Cytotoxic drugs for anticancer therapy
  • Radiopharmaceuticals for molecular imaging and theranostics
  • Contrast agents for magnetic resonance imaging (MRI)
  • Photosensitizers for photodynamic therapy (PDT)
  • CO releasing molecules (CORMs) for therapeutic applications

We are convicted that this Special Issue will contribute to awake the inorganic chemistry community for the role of metal-based compounds within biomedical applications. Thus, we would be very glad if you consider contributing to this issue by submitting an article (review, research paper or communication) in one of the topics referred above. We expect your work to be inspiring to other scientists in the field, which will certainly flourish in the next years, with positive impact in the rise of molecular and personalized medicine.

Prof. Dr. António Paulo
Prof. Dr. João D. G. Correia
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Inorganics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Metallodrugs
  • Cytotoxic Agents
  • Radiopharmaceuticals
  • Contrast Agents
  • Photosensitizers
  • CORMs

Published Papers (1 paper)

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Research

1644 KiB  
Article
Pt(IV)/Re(I) Chitosan Conjugates as a Flexible Platform for the Transport of Therapeutic and/or Diagnostic Anticancer Agents
by Elisabetta Gabano, Letícia Do Quental, Elena Perin, Francisco Silva, Paula Raposinho, António Paulo and Mauro Ravera
Inorganics 2018, 6(1), 4; https://doi.org/10.3390/inorganics6010004 - 27 Dec 2017
Cited by 7 | Viewed by 3229
Abstract
New chitosan derivatives modified with (3-carboxypropyl)trimethylammonium chloride (1) and coupled with (OC-6-44)-diammine(4-carboxypropanoato)dichloridoethanolatoplatinum(IV) (2), were synthesized and their preliminary biological evaluation carried out in human tumor cells. Some of these derivatives were also loaded with a chelating ligand [...] Read more.
New chitosan derivatives modified with (3-carboxypropyl)trimethylammonium chloride (1) and coupled with (OC-6-44)-diammine(4-carboxypropanoato)dichloridoethanolatoplatinum(IV) (2), were synthesized and their preliminary biological evaluation carried out in human tumor cells. Some of these derivatives were also loaded with a chelating ligand (3) that was derived from bis(quinolin-2-ylmethyl)amine to obtain chitosan-based nanoparticles for an EPR-mediated delivery of Pt(IV) prodrugs and Re(I) tricarbonyl complexes (4), to explore a multimodal theranostic approach to cancer. The cytotoxicity of the different chitosan conjugates (C12, C123, and C1234), carrying different combinations of the Pt(IV) complex, the chelator and the Re(I) complex, was evaluated in the A2780 human ovarian cancer cell line using the MTT assay. The Pt(IV)-containing nanosystems showed low to moderate cytotoxic activity (IC50 values in the range 13.5–33.7 µM) and was comparable to that found for the free Pt(IV) complex (IC50 = 13.7 µM). Therefore, the Pt(IV)-chitosan conjugation did not enhance the cytotoxic activity of the Pt(IV) prodrug, which certainly reflects the inefficient cellular uptake of the nanoconjugates. Nevertheless, a clearer view of their potential for the delivery of anticancer agents requires further in vivo tests because the EPR effect increases extravasation and retention within the tumor tissue, not necessarily within the tumor cells. Full article
(This article belongs to the Special Issue Metal Complexes for Imaging and Therapy)
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