Myocardial Proliferation in Development and Regeneration

Dear Colleagues,

This Special Issue of JCDD is focused on the topic of “Myocardial Prolifearation in Development and Regeneration”, which we believe to be of significant interest to many cardiac developmental biologists, stem cell biologists, and clinician scientists seeking to employ regenerative approaches to cardiovascular diseases. Recent advances in myocardial proliferation during embryogenesis and after neonatal cardiac injury has our improved understanding of the key regulatory events driving cardiac development and differentiation. They have also opened numerous areas of investigation from cell cycling in fetal cardiomyocytes to dedifferentiation of adult cardiomyocytes for regenerative applications. These exciting research pursuits have also raised important questions regarding the risks vs. benefits of inducing cardiomyocyte division in fully mature adult cardiomyocytes and the challenges that must be overcome to effectively deliver therapeutic agents to achieve improvement in overall cardiac function and long-term patient survival. In this rapidly evolving research field, we hope to illustrate the promises and the pitfalls of cardiomyocyte proliferation for normal development, and highlight key opportunities where this approach may lead to promising new therapies for cardiac regeneration.

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Atrial and ventricular cardiomyocyte
• Cardiomyocyte dedifferentiation
• Cardiomyocyte proliferation
• Myocardial development
• Myocardial regeneration
• Pluripotent stem cells