Childhood Craniopharyngioma and Hypothalamic Involvement
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Oncology".
Deadline for manuscript submissions: closed (5 December 2018)
Special Issue Editor
Interests: pediatric oncological disease; neuro-endocrinology; mechanisms of satiety regulation; hypothalamic obesity; craniopharyngioma
Special Issue Information
Dear Colleagues,
Craniopharyngiomas are rare embryonal malformations. Quality of survival, especially in case of hypothalamic tumor involvement, is impaired by severe obesity, fatigue, and psychosocial deficits. Patients with hypothalamic involvement present with reduced overall survival, whereas overall and progression-free survival are not associated with the degree of resection. Irradiation is effective in prevention of progression/recurrence. Preliminary experiences with proton beam therapy in craniopharyngioma are promising, offering a more protective radio-oncological treatment. Novel insights in molecular pathogenesis of craniopharyngiomas have offered the possibility of targeted therapy and testing this treatment in animal models. Treatment options for hypothalamic syndrome are limited. Accordingly, hypothalamus-sparing strategies are recommended. In this Special Issue, we broadly discuss basic and clinical research on childhood craniopharyngioma and hypothalamic involvement.
Prof. Dr. Hermann Müller
Guest Editor
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Keywords
- Childhood craniopharyngioma
- Molecular pathogenesis
- Embryonal malformation
- Hypothalamic syndrome
- Resection
- Proton beam therapy
- Radio-oncological treatment
