Mesenchymal Stem Cells

Dear Colleagues,

Mesenchymal stem cells (MSC), also known as mesenchymal stromal cells, continue to receive immense interest as therapies for the treatment of a diverse set of inflammatory conditions. MSCs have been reported to exert numerous anti-inflammatory pathways that allow them to suppress immune cell activation and resolve inflammation in numerous animal models and several clinical trials. Despite their advanced state in clinical trials and application in several countries around the world, fundamental questions remain. As living therapeutics, their interaction with cells in the recipient are complex and multifactorial. Further understanding of specific primary and secondary mechanisms of action of MSCs within specific treatment contexts is vital for identifying potency assays/matrices capable of predicting therapeutic efficacy. In addition, understanding the consequences of MSC interactions with the host environment, including the presence of specific immune subsets, metabolic factors, or drugs is critical to identifying patients most likely to benefit from MSC therapy.

Please join us in presenting this Special Issue on the state-of-the-art research currently being performed on MSC therapy for the treatment of various disease conditions in order to obtain a more complete picture of the many ways in which MSCs exert their therapeutic effect.

Prof. James A. Ankrum
Guest Editor

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• Mesenchymal Stem Cells
• Mesenchymal Stromal Cells
• Potency Assay
• Potency Matrix
• Mechanism of Action
• Exosomes
• Tolerance
• Cell State
• Host Interactions
• Drug Interactions